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Chao-Jung Chen

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Articles 152
Citations 1087
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Recent Articles
1.
Yang J, Huang E, Liao K, Bau D, Tsai S, Chen C, et al.
Biomedicine (Taipei) . 2025 Jan; 14(4):82-91. PMID: 39777113
Introduction: Our previous research demonstrated that a large language model (LLM) based on the transformer architecture, specifically the MegaMolBART encoder with an XGBoost classifier, effectively predicts the blood-brain barrier (BBB)...
2.
Yang C, Shie M, Huang S, Wang Y, Hou M, Chen C, et al.
Int J Biol Macromol . 2025 Jan; 295:139534. PMID: 39761885
Radiation-resistant bacteria are of great application potential in various fields, including bioindustry and bioremediation of radioactive waste. However, how radiation-resistant bacteria combat against invading phages is seldom addressed. Here, we...
3.
Lin W, Chuang C, Chen P, Chen C, Chang W, Lee M, et al.
J Ethnopharmacol . 2024 Sep; 337(Pt 1):118824. PMID: 39270880
Ethnopharmacological Relevance: Periostracum Cicadae (PC), the molted exoskeleton of the cicada Cryptotympana pustulata Fabricius, is frequently employed in Chinese herbal medicine. Based on traditional therapies and pharmacological studies, PC appears...
4.
Lee C, Liu Y, Chen C
Anal Chim Acta . 2024 Jul; 1318:342944. PMID: 39067923
Background: Protein phosphorylation by protein kinases plays a pivotal role in increasing protein diversity, thereby influencing various cellular functions. However, due to the relatively low abundance of phosphopeptides in a...
5.
Hou M, Chen C, Yang C, Wang Y, Chen Y
Nat Commun . 2024 Jul; 15(1):5634. PMID: 38965224
3',5'-cyclic uridine monophosphate (cUMP) and 3',5'-cyclic cytidine monophosphate (cCMP) have been established as bacterial second messengers in the phage defense system, named pyrimidine cyclase system for anti-phage resistance (Pycsar). This...
6.
Wang C, Yang J, Chen C, Su S, Yu H, Juan Y, et al.
Tzu Chi Med J . 2024 Apr; 36(2):152-165. PMID: 38645788
Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on...
7.
Chen C, Chang C, Lin Z, Chiu W, Liu J, Ye Z, et al.
Electrophoresis . 2023 Nov; 45(3-4):333-345. PMID: 37985935
The oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (ox-PAPC) products in human high-density lipoproteins (HDLs) were investigated by low-flow capillary electrophoresis-mass spectrometry (low-flow CE-MS). To accelerate the optimization, native PAPC (n-PAPC) standard was first analyzed...
8.
Lin C, Liao H, Lane H, Chen C
Int J Neuropsychopharmacol . 2023 Oct; 26(12):856-866. PMID: 37875373
Background: N-methyl-D-aspartate receptors (NMDARs) are crucial components of brain function involved in memory and neurotransmission. Sodium benzoate is a promising NMDAR enhancer and has been proven to be a novel,...
9.
Lee C, Jhan Y, Chiang H, Chen C
Nat Prod Res . 2023 Sep; 38(21):3848-3853. PMID: 37740591
Thirty-four phytochemicals were isolated from dry tubers of Rchb.f. The compounds were classified as bibenzyls -, dihydrophenanthrenes , , , , phenanthrenes , , , simple benzoids -, a fatty...
10.
Yang C, Ko T, Chen C, Hou M, Wang Y, Chen Y
Nat Commun . 2023 Aug; 14(1):5078. PMID: 37604815
Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive. Here, we determine the high-resolution structures of cyclic di-pyrimidine-synthesizing...