Chandrasekhar Natarajan
Overview
Explore the profile of Chandrasekhar Natarajan including associated specialties, affiliations and a list of published articles.
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39
Citations
1024
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Recent Articles
1.
Schweizer R, Ivy C, Natarajan C, Scott G, Storz J, Cheviron Z
Mol Ecol
. 2023 Apr;
32(13):3483-3496.
PMID: 37073620
Phenotypic plasticity can play an important role in the ability of animals to tolerate environmental stress, but the nature and magnitude of plastic responses are often specific to the developmental...
2.
Natarajan C, Signore A, Bautista N, Hoffmann F, Tame J, Fago A, et al.
Curr Biol
. 2022 Dec;
33(1):98-108.e4.
PMID: 36549299
The extraordinary breath-hold diving capacity of crocodilians has been ascribed to a unique mode of allosterically regulating hemoglobin (Hb)-oxygenation in circulating red blood cells. We investigated the origin and mechanistic...
3.
Ivy C, Wearing O, Natarajan C, Schweizer R, Gutierrez-Pinto N, Velotta J, et al.
J Exp Biol
. 2022 Jun;
225(11).
PMID: 35686596
No abstract available.
4.
Ivy C, Wearing O, Natarajan C, Schweizer R, Gutierrez-Pinto N, Velotta J, et al.
J Exp Biol
. 2021 Dec;
225(2).
PMID: 34913467
Physiological systems often have emergent properties but the effects of genetic variation on physiology are often unknown, which presents a major challenge to understanding the mechanisms of phenotypic evolution. We...
5.
Bautista N, Petersen E, Jensen R, Natarajan C, Storz J, Crossley 2nd D, et al.
Am J Physiol Regul Integr Comp Physiol
. 2021 Oct;
321(6):R869-R878.
PMID: 34704846
In the developing embryos of egg-laying vertebrates, O flux takes place across a fixed surface area of the eggshell and the chorioallantoic membrane. In the case of crocodilians, the developing...
6.
Bautista N, Malte H, Natarajan C, Wang T, Storz J, Fago A
J Exp Biol
. 2021 Aug;
224(15).
PMID: 34338300
Crocodilians are unique among vertebrates in that their hemoglobin (Hb) O2 binding is allosterically regulated by bicarbonate, which forms in red blood cells upon hydration of CO2. Although known for...
7.
Wearing O, Ivy C, Gutierrez-Pinto N, Velotta J, Campbell-Staton S, Natarajan C, et al.
BMC Biol
. 2021 Jun;
19(1):128.
PMID: 34158035
Background: Complex organismal traits are often the result of multiple interacting genes and sub-organismal phenotypes, but how these interactions shape the evolutionary trajectories of adaptive traits is poorly understood. We...
8.
Natarajan C, Signore A, Kumar V, Weber R, Fago A, Storz J
Biochem J
. 2020 Sep;
477(19):3839-3850.
PMID: 32936244
In vertebrate haemoglobin (Hb), the NH2-terminal residues of the α- and β-chain subunits are thought to play an important role in the allosteric binding of protons (Bohr effect), CO2 (as...
9.
Natarajan C, Signore A, Kumar V, Storz J
Curr Protoc Protein Sci
. 2020 Jul;
101(1):e112.
PMID: 32687676
The development of new technologies for the efficient expression of recombinant hemoglobin (rHb) is of interest for experimental studies of protein biochemistry and the development of cell-free blood substitutes in...
10.
Ivy C, Greaves M, Sangster E, Robertson C, Natarajan C, Storz J, et al.
J Exp Biol
. 2020 Feb;
223(Pt 5).
PMID: 32054682
High-altitude environments are cold and hypoxic, and many high-altitude natives have evolved changes in respiratory physiology that improve O uptake in hypoxia as adults. Altricial mammals undergo a dramatic metabolic...