Alpha 2.0
Login Register
» Authors » Chandrasekar Balachandran

Chandrasekar Balachandran

Explore the profile of Chandrasekar Balachandran including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 22
Citations 182
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Shin Aoki
Suresh Awale
Yuvaraj Arun
Kenta Yokoi
Jebiti Haribabu
Sivakalai Mayakrishnan
Nattamai S P Bhuvanesh
Yosuke Hisamatsu
Ramasamy Karvembu
Dya Fita Dibwe
Published In
ACS Omega
J Inorg Biochem
Org Biomol Chem
J Nat Prod
Molecules
Affiliations
Soon will be listed here.
Recent Articles
1.
Design and Synthesis of Poly(2,2'-Bipyridyl) Ligands for Induction of Cell Death in Cancer Cells: Control of Anticancer Activity by Complexation/Decomplexation with Biorelevant Metal Cations
Balachandran C, Hirose M, Tanaka T, Zhu J, Yokoi K, Hisamatsu Y, et al.
Inorg Chem . 2023 Aug; 62(36):14615-14631. PMID: 37642721
Chelation therapy is a medical procedure for removing toxic metals from human organs and tissues and for the treatment of diseases by using metal-chelating agents. For example, iron chelation therapy...
2.
Post-complexation Functionalization of Cyclometalated Iridium(III) Complexes and Applications to Biomedical and Material Sciences
Aoki S, Yokoi K, Hisamatsu Y, Balachandran C, Tamura Y, Tanaka T
Top Curr Chem (Cham) . 2022 Aug; 380(5):36. PMID: 35948812
Cyclometalated iridium(III) (Ir(III)) complexes exhibit excellent photophysical properties that include large Stokes shift, high emission quantum yields, and microsecond-order emission lifetimes, due to low-lying metal-to-ligand charge transfer (spin-forbidden singlet-triplet (MLCT)...
3.
Cyclometalated Iridium(III) Complex-Cationic Peptide Hybrids Trigger Paraptosis in Cancer Cells via an Intracellular Ca Overload from the Endoplasmic Reticulum and a Decrease in Mitochondrial Membrane Potential
Balachandran C, Yokoi K, Naito K, Haribabu J, Tamura Y, Umezawa M, et al.
Molecules . 2021 Nov; 26(22). PMID: 34834120
In our previous paper, we reported that amphiphilic Ir complex-peptide hybrids (IPHs) containing basic peptides such as KK(K)GG (K: lysine, G: glycine) (e.g., ASb-2) exhibited potent anticancer activity against Jurkat...
4.
Rh(iii)-Catalysed synthesis of cinnolinium and fluoranthenium salts using C-H activation/annulation reactions: organelle specific mitochondrial staining applications
Mayakrishnan S, Tamizmani M, Balachandran C, Aoki S, Maheswari N
Org Biomol Chem . 2021 May; 19(24):5413-5425. PMID: 34047328
The construction of a novel class of indazolo[2,1-a]cinnolin-7-ium and diazabenzofluoranthenium salts was developed by using Rh(iii)-catalyzed C-H activation/annulation reactions with 2-phenyl-2H-indazole, and internal alkynes, which resulted in structurally important polycyclic...
5.
N-substitution in isatin thiosemicarbazones decides nuclearity of Cu(II) complexes - Spectroscopic, molecular docking and cytotoxic studies
Haribabu J, Alajrawy O, Jeyalakshmi K, Balachandran C, Krishnan D, Bhuvanesh N, et al.
Spectrochim Acta A Mol Biomol Spectrosc . 2020 Oct; 246:118963. PMID: 33017789
The mono- (1) and bi-nuclear (2) copper(II) complexes containing N-substituted isatin thiosemicarbazone(s) were synthesized, and characterized by analytical and spectroscopic (UV-Visible, FT-IR and EPR) techniques. Bimetallic nature of complex 2...
6.
Synthesis, characterization, theoretical, molecular docking and biological activity studies of Ru(II) (--cymene) complexes with novel aniline substituted aroyl selenoureas
Musthafa M, Konakanchi R, Ganguly R, Balachandran C, Aoki S, Sreekanth A
J Biomol Struct Dyn . 2020 Jun; 39(12):4346-4361. PMID: 32597724
A sequence of aroyl selenourea ligands ( substituted by aniline and their Ru(II) (--cymene) complexes , [Ru(II) (--cymene) L] (L = monodentate aroyl selenourea ligand) have been synthesized and characterized...
7.
ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy
Ayyanaar S, Balachandran C, Bhaskar R, Kesavan M, Aoki S, Raja R, et al.
Int J Nanomedicine . 2020 Jun; 15:3333-3346. PMID: 32494133
Background And Objective: Cancer cells accumulate high concentrations of reactive oxygen species as a result of their faster and uninhibited metabolic activity. Cancer chemotherapeutic agents release an excess of severe...
8.
Amphiphilic Cationic Triscyclometalated Iridium(III) Complex-Peptide Hybrids Induce Paraptosis-like Cell Death of Cancer Cells via an Intracellular Ca-Dependent Pathway
Yokoi K, Balachandran C, Umezawa M, Tsuchiya K, Mitric A, Aoki S
ACS Omega . 2020 Apr; 5(12):6983-7001. PMID: 32258934
We report on the design and synthesis of a green-emitting iridium complex-peptide hybrid (IPH) , which has an electron-donating hydroxyacetic acid (glycolic acid) moiety between the Ir core and the...
9.
Unprecedented formation of palladium(II)-pyrazole based thiourea from chromone thiosemicarbazone and [PdCl(PPh)]: Interaction with biomolecules and apoptosis through mitochondrial signaling pathway
Haribabu J, Balachandran C, Tamizh M, Arun Y, Bhuvanesh N, Aoki S, et al.
J Inorg Biochem . 2020 Jan; 205:110988. PMID: 31981770
Two novel pyrazole based thiourea palladium(II) complexes, [PdCl(PPh)(CHNOS-pz)] (1) and [PdCl(PPh)(CHNOS-pz)] (2) [pz = pyrazole (CHN)] have been obtained unexpectedly from chromone thiosemicarbazones (L1 and L2) and [PdCl(PPh)]. The compounds...
10.
Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery
Ayyanaar S, Kesavan M, Balachandran C, Rasala S, Rameshkumar P, Aoki S, et al.
Nanomedicine . 2019 Dec; 24:102134. PMID: 31830615
This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (FeO NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug...