Chad K Nicholson
Overview
Explore the profile of Chad K Nicholson including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
1113
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0
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Recent Articles
1.
Shimizu Y, Nicholson C, Polavarapu R, Pantner Y, Husain A, Naqvi N, et al.
J Am Heart Assoc
. 2020 Feb;
9(4):e014691.
PMID: 32067589
Background DJ-1 is a ubiquitously expressed protein typically associated with the development of early onset Parkinson disease. Recent data suggest that it also plays a role in the cellular response...
2.
Shimizu Y, Polavarapu R, Eskla K, Pantner Y, Nicholson C, Ishii M, et al.
J Am Heart Assoc
. 2018 Oct;
7(19):e009565.
PMID: 30371303
Background Lymphatic vessels interconnect with blood vessels to form an elaborate system that aids in the control of tissue pressure and edema formation. Although the lymphatic system has been known...
3.
Shimizu Y, Polavarapu R, Eskla K, Nicholson C, Koczor C, Wang R, et al.
J Mol Cell Cardiol
. 2018 Feb;
116:29-40.
PMID: 29408195
Background: Hydrogen sulfide (HS) is an important regulator of mitochondrial bioenergetics, but its role in regulating mitochondrial biogenesis is not well understood. Using both genetic and pharmacological approaches, we sought...
4.
Li M, Tejada T, Lambert J, Nicholson C, Yahiro E, Ambai V, et al.
Am J Cardiovasc Dis
. 2016 Sep;
6(3):118-28.
PMID: 27679746
Angiotensin II (Ang II) modulates blood pressure and atherosclerosis development through its vascular type-1 (AT1R) and type-2 (AT2R) receptors, which have opposing effects. AT2R activation produces hypotension, and is anti-atherogenic....
5.
Shimizu Y, Lambert J, Nicholson C, Kim J, Wolfson D, Cho H, et al.
J Mol Cell Cardiol
. 2016 Apr;
97:56-66.
PMID: 27108530
Recent data indicates that DJ-1 plays a role in the cellular response to stress. Here, we aimed to examine the underlying molecular mechanisms mediating the actions of DJ-1 in the...
6.
Shimizu Y, Nicholson C, Lambert J, Barr L, Kuek N, Herszenhaut D, et al.
Circ Heart Fail
. 2016 Apr;
9(4):e002368.
PMID: 27056879
Background: Therapeutic strategies aimed at increasing hydrogen sulfide (H2S) levels exert cytoprotective effects in various models of cardiovascular injury. However, the underlying mechanism(s) responsible for this protection remain to be...
7.
Barr L, Shimizu Y, Lambert J, Nicholson C, Calvert J
Nitric Oxide
. 2015 Jan;
46:145-56.
PMID: 25575644
Diabetic cardiomyopathy is a significant contributor to the morbidity and mortality associated with diabetes and metabolic syndrome. However, the underlying molecular mechanisms that lead to its development have not been...
8.
Lambert J, Nicholson C, Amin H, Amin S, Calvert J
Med Gas Res
. 2014 Dec;
4(1):20.
PMID: 25525500
Background: Coronary artery disease remains the principal cause of death in patients with diabetes mellitus. Diabetic mice display exacerbated injury following myocardial ischemia-reperfusion (MI/R) and are resistant to most therapeutic...
9.
Bhushan S, Kondo K, Polhemus D, Otsuka H, Nicholson C, Tao Y, et al.
Circ Res
. 2014 Mar;
114(8):1281-91.
PMID: 24599803
Rationale: Nitric oxide (NO) bioavailability is reduced in the setting of heart failure. Nitrite (NO2) is a critically important NO intermediate that is metabolized to NO during pathological states. We...
10.
King A, Polhemus D, Bhushan S, Otsuka H, Kondo K, Nicholson C, et al.
Proc Natl Acad Sci U S A
. 2014 Feb;
111(8):3182-7.
PMID: 24516168
Previous studies have demonstrated that hydrogen sulfide (H2S) protects against multiple cardiovascular disease states in a similar manner as nitric oxide (NO). H2S therapy also has been shown to augment...