Cesare Montecucco
Overview
Explore the profile of Cesare Montecucco including associated specialties, affiliations and a list of published articles.
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163
Citations
4096
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Recent Articles
1.
McGorum B, Pirie R, Bano L, Davey T, Harris J, Montecucco C
Equine Vet J
. 2024 Dec;
57(1):11-18.
PMID: 39630613
No abstract available.
2.
Fabris F, Megighian A, Rossetto O, Simonato M, Schiavo G, Pirazzini M, et al.
Am J Pathol
. 2024 Jun;
194(9):1752-1763.
PMID: 38885925
Local tetanus develops when limited amounts of tetanus neurotoxin (TeNT) are released by Clostridium tetani generated from spores inside a necrotic wound. Within days, a spastic paralysis restricted to the...
3.
4.
DEste G, Fabris F, Stazi M, Baggio C, Simonato M, Megighian A, et al.
PLoS Negl Trop Dis
. 2024 Jan;
18(1):e0011825.
PMID: 38190386
Snake envenoming is a major, but neglected, tropical disease. Among venomous snakes, those inducing neurotoxicity such as kraits (Bungarus genus) cause a potentially lethal peripheral neuroparalysis with respiratory deficit in...
5.
Rossetto O, Pirazzini M, Montecucco C
Trends Neurosci
. 2023 Jun;
46(9):695-697.
PMID: 37385877
Joensuu and colleagues have recently shown that botulinum neurotoxin (BoNT) type A exploits a heterotrimeric complex in the presynaptic membrane to bind to and enter neurons using a Trojan horse-like...
6.
Fabris F, Varani S, Tonellato M, Matak I, Sostaric P, Meglic P, et al.
JCI Insight
. 2023 May;
8(11).
PMID: 37159261
Cephalic tetanus (CT) is a severe form of tetanus that follows head wounds and the intoxication of cranial nerves by tetanus neurotoxin (TeNT). Hallmarks of CT are cerebral palsy, which...
7.
Stazi M, Fabris F, Fernandez J, DEste G, Rigoni M, Megighian A, et al.
Toxins (Basel)
. 2022 Aug;
14(8).
PMID: 36006193
Snake envenoming is a major but neglected human disease in tropical and subtropical regions. Among venomous snakes in the Americas, coral snakes of the genus are particularly dangerous because they...
8.
Fabris F, Sostaric P, Matak I, Binz T, Toffan A, Simonato M, et al.
Int J Mol Sci
. 2022 Apr;
23(8).
PMID: 35457172
Tetanus and Botulinum type B neurotoxins are bacterial metalloproteases that specifically cleave the vesicle-associated membrane protein VAMP at an identical peptide bond, resulting in inhibition of neuroexocytosis. The minute amounts...
9.
Pirazzini M, Montecucco C, Rossetto O
Arch Toxicol
. 2022 Mar;
96(6):1521-1539.
PMID: 35333944
Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and botulism, respectively, by delivering inside different types of neurons, metalloproteases specifically cleaving the SNARE proteins that are essential for...
10.
DEste G, Stazi M, Negro S, Megighian A, Lista F, Rossetto O, et al.
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163106
We used α-Latrotoxin (α-LTx), the main neurotoxic component of the black widow spider venom, which causes degeneration of the neuromuscular junction (NMJ) followed by a rapid and complete regeneration, as...