Celio X C Santos
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Explore the profile of Celio X C Santos including associated specialties, affiliations and a list of published articles.
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34
Citations
1767
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Recent Articles
11.
Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, et al.
Nat Cell Biol
. 2018 Mar;
20(9):1098.
PMID: 29520084
In the version of this Article originally published, the affiliations for Roland A. Fleck and José Antonio Del Río were incorrect due to a technical error that resulted in affiliations...
12.
Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, et al.
Nat Cell Biol
. 2018 Feb;
20(3):307-319.
PMID: 29434374
Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by the inflammatory response after injury. Here we show that ROS, which promote axonal dieback and degeneration after injury,...
13.
Sag C, Schnelle M, Zhang J, Murdoch C, Kossmann S, Protti A, et al.
Circulation
. 2017 Mar;
135(22):2163-2177.
PMID: 28298457
Background: Hypertension caused by increased renin-angiotensin system activation is associated with elevated reactive oxygen species production. Previous studies implicate NADPH oxidase (Nox) proteins as important reactive oxygen species sources during...
14.
Viswambharan H, Yuldasheva N, Sengupta A, Imrie H, Gage M, Haywood N, et al.
Circ Res
. 2016 Dec;
120(5):784-798.
PMID: 27920123
Rationale: In the endothelium, insulin stimulates endothelial NO synthase (eNOS) to generate the antiatherosclerotic signaling radical NO. Insulin-resistant type 2 diabetes mellitus is associated with reduced NO availability and accelerated...
15.
Guentsch A, Beneke A, Swain L, Farhat K, Nagarajan S, Wielockx B, et al.
Mol Cell Biol
. 2016 Nov;
37(1).
PMID: 27795296
The prolyl-4-hydroxylase domain (PHD) enzymes are regarded as the molecular oxygen sensors. There is an interplay between oxygen availability and cellular metabolism, which in turn has significant effects on the...
16.
Sirker A, Murdoch C, Protti A, Sawyer G, Santos C, Martin D, et al.
J Mol Cell Cardiol
. 2016 Jul;
98:11-7.
PMID: 27397876
Background: Increased reactive oxygen species (ROS) production is involved in the process of adverse cardiac remodeling and development of heart failure after myocardial infarction (MI). NADPH oxidase-2 (Nox2) is a...
17.
Santos C, Raza S, Shah A
Int J Biochem Cell Biol
. 2016 Mar;
74:145-51.
PMID: 26987585
The specific effect of oxygen and reactive oxygen species (ROS) in mediating post-translational modification of protein targets has emerged as a key mechanism regulating signaling components, a process termed redox...
18.
Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling
Santos C, Hafstad A, Beretta M, Zhang M, Molenaar C, Kopec J, et al.
EMBO J
. 2016 Jan;
35(3):319-34.
PMID: 26742780
Phosphorylation of translation initiation factor 2α (eIF2α) attenuates global protein synthesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolutionarily conserved adaptive pathway during cellular...
19.
Sag C, Santos C, Shah A
J Mol Cell Cardiol
. 2014 Feb;
73:103-11.
PMID: 24530760
It is increasingly evident that redox-dependent modifications in cellular proteins and signaling pathways (or redox signaling) play important roles in many aspects of cardiac hypertrophy. Indeed, these redox modifications may...
20.
Santos C, Nabeebaccus A, Shah A, Camargo L, Filho S, Lopes L
Antioxid Redox Signal
. 2013 Mar;
20(1):121-34.
PMID: 23472786
Significance: Reactive oxygen species (ROS) are produced during normal endoplasmic reticulum (ER) metabolism. There is accumulating evidence showing that under stress conditions such as ER stress, ROS production is increased...