Celine M Dube
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Explore the profile of Celine M Dube including associated specialties, affiliations and a list of published articles.
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16
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980
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Recent Articles
1.
Garcia-Curran M, Hall A, Patterson K, Shao M, Eltom N, Chen K, et al.
eNeuro
. 2019 Nov;
6(6).
PMID: 31685676
The role of neuroinflammation in the mechanisms of epilepsy development is important because inflammatory mediators provide tractable targets for intervention. Inflammation is intrinsically involved in the generation of childhood febrile...
2.
Curran M, Haddad E, Patterson K, Choy M, Dube C, Baram T, et al.
Epilepsia
. 2018 Sep;
59(11):2005-2018.
PMID: 30256385
Objective: A subset of children with febrile status epilepticus (FSE) are at risk for development of temporal lobe epilepsy later in life. We sought a noninvasive predictive marker of those...
3.
Brennan G, Dey D, Chen Y, Patterson K, Magnetta E, Hall A, et al.
Cell Rep
. 2016 Mar;
14(10):2402-12.
PMID: 26947066
Insult-provoked transformation of neuronal networks into epileptic ones involves multiple mechanisms. Intervention studies have identified both dysregulated inflammatory pathways and NRSF-mediated repression of crucial neuronal genes as contributors to epileptogenesis....
4.
Dube C, Molet J, Singh-Taylor A, Ivy A, Maras P, Baram T
Neurobiol Stress
. 2015 Apr;
2:10-19.
PMID: 25884016
Epilepsy is more prevalent in populations with high measures of stress, but the neurobiological mechanisms are unclear. Stress is a common precipitant of seizures in individuals with epilepsy, and may...
5.
Choy M, Dube C, Patterson K, Barnes S, Maras P, Blood A, et al.
J Neurosci
. 2014 Jun;
34(26):8672-84.
PMID: 24966369
A significant proportion of temporal lobe epilepsy (TLE), a common, intractable brain disorder, arises in children with febrile status epilepticus (FSE). Preventative therapy development is hampered by our inability to...
6.
Choy M, Dube C, Ehrengruber M, Baram T
Epilepsy Curr
. 2014 Jun;
14(1 Suppl):15-22.
PMID: 24955071
Febrile seizures (FS) are the most common type of seizures in infants and preschool children. Inflammatory mediators, which are known triggers of fever, have also been implicated as contributors to...
7.
McClelland S, Dube C, Yang J, Baram T
Neurosci Lett
. 2011 Mar;
497(3):155-62.
PMID: 21356275
Epidemiological and recent prospective analyses of long febrile seizures (FS) and febrile status epilepticus (FSE) support the idea that in some children, such seizures can provoke temporal lobe epilepsy (TLE)....
8.
Hill E, Hosie S, Mulligan R, Richards K, Davies P, Dube C, et al.
Epilepsia
. 2011 Jan;
52(1):179-84.
PMID: 21219304
A missense mutation (R43Q) in the γ2 subunit of the γ-aminobutyric acid (GABA)(A) receptor is associated with generalized (genetic) epilepsy with febrile seizures plus (GEFS+). Heterozygous GABA(A) γ2(R43Q) mice displayed...
9.
Chen Y, Rex C, Rice C, Dube C, Gall C, Lynch G, et al.
Proc Natl Acad Sci U S A
. 2010 Jul;
107(29):13123-8.
PMID: 20615973
Stress affects the hippocampus, a brain region crucial for memory. In rodents, acute stress may reduce density of dendritic spines, the location of postsynaptic elements of excitatory synapses, and impair...
10.
Dube C, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, et al.
J Neurosci
. 2010 Jun;
30(22):7484-94.
PMID: 20519523
Whether long febrile seizures (FSs) can cause epilepsy in the absence of genetic or acquired predisposing factors is unclear. Having established causality between long FSs and limbic epilepsy in an...