Catherine C Robertson
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Explore the profile of Catherine C Robertson including associated specialties, affiliations and a list of published articles.
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23
Citations
449
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Recent Articles
1.
Crouch D, Inshaw J, Robertson C, Ng E, Zhang J, Chen W, et al.
Genet Epidemiol
. 2025 Jan;
49(1):e22608.
PMID: 39749473
Biological datasets often consist of thousands or millions of variables, e.g. genetic variants or biomarkers, and when sample sizes are large it is common to find many associated with an...
2.
Yang L, Han Y, Zhang T, Dong X, Ge J, Roy A, et al.
Cell Stem Cell
. 2024 Sep;
31(11):1612-1629.e8.
PMID: 39232561
There is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples,...
3.
Yang L, Han Y, Zhang T, Dong X, Ge J, Roy A, et al.
bioRxiv
. 2024 Aug;
PMID: 39149298
There is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples,...
4.
Grenko C, Taylor H, Bonnycastle L, Xue D, Lee B, Weiss Z, et al.
Diabetologia
. 2024 Jul;
67(10):2246-2259.
PMID: 38967666
Aims/hypothesis: Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell glucotoxicity and subsequently type 2 diabetes. In this study, we explored...
5.
Robertson C, Elgamal R, Henry-Kanarek B, Arvan P, Chen S, Dhawan S, et al.
Mol Metab
. 2024 Jun;
86:101973.
PMID: 38914291
Background: Type 1 diabetes (T1D) is a complex multi-system disease which arises from both environmental and genetic factors, resulting in the destruction of insulin-producing pancreatic beta cells. Over the past...
6.
Michalek D, Tern C, Zhou W, Robertson C, Farber E, Campolieto P, et al.
Hum Mol Genet
. 2024 Mar;
33(11):958-968.
PMID: 38453145
Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of the pancreatic β-cells. Genome-wide association (GWAS) and fine mapping studies have been conducted mainly in European ancestry (EUR)...
7.
Bonnycastle L, Swift A, Mansell E, Lee A, Winnicki E, Li E, et al.
CRISPR J
. 2024 Feb;
7(1):53-67.
PMID: 38353623
We developed an efficient CRISPR prime editing protocol and generated isogenic-induced pluripotent stem cell (iPSC) lines carrying heterozygous or homozygous alleles for putatively causal single nucleotide variants at six type...
8.
Grenko C, Bonnycastle L, Taylor H, Yan T, Swift A, Robertson C, et al.
bioRxiv
. 2023 Jun;
PMID: 37333221
Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycemia, beta cell glucotoxicity, and ultimately type 2 diabetes (T2D). In this study, we sought...
9.
Richardson T, Crouch D, Power G, Morales-Berstein F, Hazelwood E, Fang S, et al.
Nat Commun
. 2022 Apr;
13(1):2337.
PMID: 35484151
The rising prevalence of childhood obesity has been postulated as an explanation for the increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use Mendelian...
10.
Robertson C, Inshaw J, Onengut-Gumuscu S, Chen W, Santa Cruz D, Yang H, et al.
Nat Genet
. 2021 Jun;
53(7):962-971.
PMID: 34127860
We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide-significant (P < 5 × 10) regions, including 36 that...