Cassandra D Belair
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Explore the profile of Cassandra D Belair including associated specialties, affiliations and a list of published articles.
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11
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981
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Recent Articles
1.
Yang J, Wang L, Byrnes J, Kirkemo L, Driks H, Belair C, et al.
Cancer Immunol Res
. 2024 Apr;
12(5):575-591.
PMID: 38588410
Poliovirus receptor-related 2 (PVRL2, also known as nectin-2 or CD112) is believed to act as an immune checkpoint protein in cancer; however, most insight into its role is inferred from...
2.
Dole N, Yoon J, Monteiro D, Yang J, Mazur C, Kaya S, et al.
FASEB J
. 2021 Sep;
35(10):e21883.
PMID: 34569659
Organism scale mechanical forces elicit cellular scale changes through coordinated regulation of multiple signaling pathways. The mechanisms by which cells integrate signaling to generate a unified biological response remains a...
3.
Monteiro D, Dole N, Campos J, Kaya S, Schurman C, Belair C, et al.
FASEB J
. 2021 Feb;
35(3):e21263.
PMID: 33570811
Bone is a dynamic tissue that constantly adapts to changing mechanical demands. The transforming growth factor beta (TGFβ) signaling pathway plays several important roles in maintaining skeletal homeostasis by both...
4.
Zhou X, Nair G, Russ H, Belair C, Li M, Shveygert M, et al.
Stem Cell Reports
. 2019 Dec;
14(1):9-20.
PMID: 31883920
Differentiation of human embryonic stem cells into pancreatic β cells holds great promise for the treatment of diabetes. Recent advances have led to the production of glucose-responsive insulin-secreting cells in ...
5.
Poggio M, Hu T, Pai C, Chu B, Belair C, Chang A, et al.
Cell
. 2019 Apr;
177(2):414-427.e13.
PMID: 30951669
PD-L1 on the surface of tumor cells binds its receptor PD-1 on effector T cells, thereby suppressing their activity. Antibody blockade of PD-L1 can activate an anti-tumor immune response leading...
6.
High-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing
Belair C, Hu T, Chu B, Freimer J, Cooperberg M, Blelloch R
Sci Rep
. 2019 Feb;
9(1):2262.
PMID: 30783180
MicroRNAs hold great promise as biomarkers of disease. However, there are few efficient and robust methods for measuring microRNAs from low input samples. Here, we develop a high-throughput sequencing protocol...
7.
Paikari A, Belair C, Saw D, Blelloch R
Development
. 2017 Sep;
144(20):3731-3743.
PMID: 28935707
The vertebrate-specific ESCC microRNA family arises from two genetic loci in mammals: miR-290/miR-371 and miR-302. The miR-302 locus is found broadly among vertebrates, whereas the miR-290/miR-371 locus is unique to...
8.
Belair C, Paikari A, Moltzahn F, Shenoy A, Yau C, DallEra M, et al.
EMBO Rep
. 2015 Jul;
16(9):1219-32.
PMID: 26206718
In human prostate cancer, the microRNA biogenesis machinery increases with prostate cancer progression. Here, we show that deletion of the Dgcr8 gene, a critical component of this complex, inhibits tumor...
9.
Wang S, Shiboski S, Belair C, Cooperberg M, Simko J, Stoppler H, et al.
PLoS One
. 2014 Jun;
9(6):e98597.
PMID: 24893170
Serum microRNAs hold great promise as easily accessible and measurable biomarkers of disease. In prostate cancer, serum miRNA signatures have been associated with the presence of disease as well as...
10.
Subramanyam D, Belair C, Barry-Holson K, Lin H, Kogan S, Passegue E, et al.
Cancer Res
. 2010 Sep;
70(21):8792-801.
PMID: 20861188
The PML-RARα oncogene is the central effector of acute promyelocytic leukemia (APL). PML-RARα physically interacts with epigenetic-modifying enzymes including DNA methyltransferases (Dnmt) to suppress critical downstream targets. Here, we show...