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Carter J Wilson

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Articles 7
Citations 82
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Recent Articles
1.
Wilson C, de Groot B, Gapsys V
J Comput Chem . 2024 Mar; 45(17):1444-1455. PMID: 38471815
In a protein, nearby titratable sites can be coupled: the (de)protonation of one may affect the other. The degree of this interaction depends on several factors and can influence the...
2.
Huang P, Abacka H, Wilson C, Wind M, Rutzler M, Hagstrom-Andersson A, et al.
Proc Natl Acad Sci U S A . 2024 Feb; 121(7):e2319682121. PMID: 38319972
Cancer invasion and metastasis are known to be potentiated by the expression of aquaporins (AQPs). Likewise, the expression levels of AQPs have been shown to be prognostic for survival in...
3.
Wilson C, Karttunen M, de Groot B, Gapsys V
J Chem Theory Comput . 2023 Oct; 19(21):7833-7845. PMID: 37820376
The stability, solubility, and function of a protein depend on both its net charge and the protonation states of its individual residues. p is a measure of the tendency for...
4.
Wilson C, Choy W, Karttunen M
Int J Mol Sci . 2022 May; 23(9). PMID: 35562983
The development of AlphaFold2 marked a paradigm-shift in the structural biology community. Herein, we assess the ability of AlphaFold2 to predict disordered regions against traditional sequence-based disorder predictors. We find...
5.
Salem A, Wilson C, Rutledge B, Dilliott A, Farhan S, Choy W, et al.
Front Mol Biosci . 2022 Jan; 8:794646. PMID: 35083279
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of both upper and lower motor neurons in the brain and spinal cord. ALS is associated with protein...
6.
Wilson C, Chang M, Karttunen M, Choy W
Int J Mol Sci . 2021 Jun; 22(10). PMID: 34065616
We have performed 280 μs of unbiased molecular dynamics (MD) simulations to investigate the effects of 12 different cancer mutations on Kelch-like ECH-associated protein 1 (KEAP1) (G333C, G350S, G364C, G379D,...
7.
Chang M, Wilson C, Karunatilleke N, Moselhy M, Karttunen M, Choy W
J Chem Theory Comput . 2021 Apr; 17(5):3145-3156. PMID: 33861593
The nuclear factor erythroid 2-related factor 2 (Nrf2)-ARE transcriptional response pathway plays a critical role in protecting the cell from oxidative stresses via the upregulation of cytoprotective genes. Aberrant activation...