Carsten Peukert
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Explore the profile of Carsten Peukert including associated specialties, affiliations and a list of published articles.
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9
Citations
52
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Recent Articles
1.
Ramming I, Lang C, Hauf S, Kruger M, Worbs S, Peukert C, et al.
ACS Infect Dis
. 2024 Nov;
10(12):4103-4114.
PMID: 39576816
Shiga-toxin-producing (STEC) are important human pathogens causing diarrhea, hemorrhagic colitis, and severe hemolytic uremic syndrome. Timely detection of the multifaceted STEC is of high importance but is challenging and labor-intensive....
2.
Weber B, Ritchie N, Hilker S, Chan D, Peukert C, Deisinger J, et al.
ACS Infect Dis
. 2024 Oct;
10(11):3821-3841.
PMID: 39438291
To cause infection, bacterial pathogens must overcome host immune factors and barriers to nutrient acquisition. Reproducing these aspects of host physiology in vitro has shown great promise for antibacterial drug...
3.
Peukert C, Vetter A, Fuchs H, Harmrolfs K, Karge B, Stadler M, et al.
Chem Sci
. 2023 May;
14(20):5490-5502.
PMID: 37234900
The growing antibiotic resistance, foremost in Gram-negative bacteria, requires novel therapeutic approaches. We aimed to enhance the potency of well-established antibiotics targeting the RNA polymerase (RNAP) by utilizing the microbial...
4.
Peukert C, Rox K, Karge B, Hotop S, Bronstrup M
ACS Infect Dis
. 2023 Jan;
9(2):330-341.
PMID: 36719860
The rise of antimicrobial resistance, especially in Gram-negative bacteria, calls for novel diagnostics and antibiotics. To efficiently penetrate their double-layered cell membrane, we conjugated the potent antibiotics daptomycin, vancomycin, and...
5.
Peukert C, Gasser V, Orth T, Fritsch S, Normant V, Cunrath O, et al.
J Med Chem
. 2022 Dec;
66(1):553-576.
PMID: 36548006
Rising infection rates with multidrug-resistant pathogens calls for antibiotics with novel modes of action. Herein, we identify the inner membrane protein TonB, a motor of active uptake in Gram-negative bacteria,...
6.
Fritsch S, Gasser V, Peukert C, Pinkert L, Kuhn L, Perraud Q, et al.
ACS Infect Dis
. 2022 May;
8(6):1134-1146.
PMID: 35500104
The development of new antibiotics against Gram-negative bacteria has to deal with the low permeability of the outer membrane. This obstacle can be overcome by utilizing siderophore-dependent iron uptake pathways...
7.
Peukert C, Popat Gholap S, Green O, Pinkert L, van den Heuvel J, van Ham M, et al.
Angew Chem Int Ed Engl
. 2022 Mar;
61(25):e202201423.
PMID: 35358362
The sensitive detection of bacterial infections is a prerequisite for their successful treatment. The use of a chemiluminescent readout was so far hampered by an insufficient probe enrichment at the...
8.
Pinkert L, Lai Y, Peukert C, Hotop S, Karge B, Schulze L, et al.
J Med Chem
. 2021 Oct;
64(20):15440-15460.
PMID: 34619959
The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the...
9.
Peukert C, Langer L, Wegener S, Tutov A, Bankstahl J, Karge B, et al.
J Med Chem
. 2021 Aug;
64(16):12359-12378.
PMID: 34370949
The diagnosis of bacterial infections at deep body sites benefits from noninvasive imaging of molecular probes that can be traced by positron emission tomography (PET). We specifically labeled bacteria by...