Carsten E Stidsen
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Explore the profile of Carsten E Stidsen including associated specialties, affiliations and a list of published articles.
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11
Citations
214
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Recent Articles
1.
Hvid H, Brand C, Hummelshoj T, Jensen S, Bouman S, Bowler A, et al.
Diabetologia
. 2022 Nov;
66(2):376-389.
PMID: 36404376
Aims/hypothesis: Normalisation of blood glucose in individuals with diabetes is recommended to reduce development of diabetic complications. However, risk of severe hypoglycaemia with intensive insulin therapy is a major obstacle...
2.
Tagmose T, Pedersen K, Pridal L, Stidsen C, Pedersen M, Lin Z, et al.
J Med Chem
. 2022 Feb;
65(3):2633-2645.
PMID: 35104142
Here, we describe molecular engineering of monovalent ultra-long acting two-chain insulin-Fc conjugates. Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue...
3.
Kjeldsen T, Hubalek F, Hjorringgaard C, Tagmose T, Nishimura E, Stidsen C, et al.
J Med Chem
. 2021 May;
64(13):8942-8950.
PMID: 33944562
Here, we describe the molecular engineering of insulin icodec to achieve a plasma half-life of 196 h in humans, suitable for once-weekly subcutaneously administration. Insulin icodec is based on re-engineering...
4.
Kjeldsen T, Hubalek F, Tagmose T, Pridal L, Refsgaard H, Porsgaard T, et al.
J Med Chem
. 2020 Dec;
64(1):616-628.
PMID: 33356257
Recently, the first basal oral insulin (OI338) was shown to provide similar treatment outcomes to insulin glargine in a phase 2a clinical trial. Here, we report the engineering of a...
5.
Kjeldsen T, Hogendorf W, Tornoe C, Anderson J, Hubalek F, Stidsen C, et al.
ACS Omega
. 2020 Aug;
5(31):19827-19833.
PMID: 32803078
Covalent cross-linking of biomolecules can be useful in pursuit of tissue targeting or dual targeting of two receptors on cell surfaces for avidity effects. Long linkers (>10 kDa) can be...
6.
Glendorf T, Knudsen L, Stidsen C, Hansen B, Hegelund A, Sorensen A, et al.
PLoS One
. 2012 Mar;
7(2):e29198.
PMID: 22383948
Background: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have...
7.
Vienberg S, Bouman S, Sorensen H, Stidsen C, Kjeldsen T, Glendorf T, et al.
Biochem J
. 2011 Aug;
440(3):301-8.
PMID: 21851336
The relative expression patterns of the two IR (insulin receptor) isoforms, +/- exon 11 (IR-B/IR-A respectively), are tissue-dependent. Therefore we have developed insulin analogues with different binding affinities for the...
8.
Glendorf T, Stidsen C, Norrman M, Nishimura E, Sorensen A, Kjeldsen T
PLoS One
. 2011 Jun;
6(5):e20288.
PMID: 21625452
Background: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor...
9.
Holst B, Egerod K, Schild E, Vickers S, Cheetham S, Gerlach L, et al.
Endocrinology
. 2006 Sep;
148(1):13-20.
PMID: 16959833
GPR39 is an orphan member of the ghrelin receptor family that recently was suggested to be the receptor for obestatin, a peptide derived from the ghrelin precursor. Here, we compare...
10.
Grondahl C, Breinholt J, Wahl P, Murray A, Hansen T, Faerge I, et al.
Hum Reprod
. 2003 Jan;
18(1):122-9.
PMID: 12525452
Background: In the context of mammalian oocyte maturation, it has been suggested that intermediates of cholesterol biosynthesis may represent the physiological signal that instructs the oocyte to reinitiate meiosis. Methods:...