Caroline Nothdurfter
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Explore the profile of Caroline Nothdurfter including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Riebel M, Brunner L, Nothdurfter C, Wein S, Schwarzbach J, Liere P, et al.
Eur Arch Psychiatry Clin Neurosci
. 2024 Jul;
PMID: 38976049
Recently, the gamma-aminobutyric acid (GABA) system has come into focus for the treatment of anxiety, postpartum depression, and major depressive disorder. Endogenous 3α-reduced steroids such as allopregnanolone are potent positive...
2.
Wein S, Riebel M, Seidel P, Brunner L, Wagner V, Nothdurfter C, et al.
Neuropsychopharmacology
. 2024 May;
49(11):1738-1748.
PMID: 38822128
TSPO ligands are promising alternatives to benzodiazepines in the treatment of anxiety, as they display less pronounced side effects such as sedation, cognitive impairment, tolerance development and abuse potential. In...
3.
Brunner L, Riebel M, Wein S, Koller M, Zeman F, Huppertz G, et al.
Trials
. 2024 Apr;
25(1):274.
PMID: 38650030
Background: Recent developments suggest that neurosteroids may achieve rapid antidepressant effects. As such, neurosteroidogenesis mediated by the translocator protein 18 kDa (TSPO) might constitute a promising option for the treatment...
4.
Cardon I, Grobecker S, Kucukoktay S, Bader S, Jahner T, Nothdurfter C, et al.
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38256041
The link between mitochondria and major depressive disorder (MDD) is increasingly evident, underscored both by mitochondria's involvement in many mechanisms identified in depression and the high prevalence of MDD in...
5.
Manook A, Baghai T, Riebel M, Nothdurfter C, Schwarzbach J, Gessner A, et al.
Front Neurosci
. 2023 Dec;
17:1188847.
PMID: 38075272
Background: Neurosteroids have recently gained in interest as a treatment strategy for affective disorders. Etifoxine is known for its dual mode of action, one of which is to stimulate endogenous...
6.
Riebel M, von Pappenheim B, Kanig C, Nothdurfter C, Wetter T, Rupprecht R, et al.
Pharmacopsychiatry
. 2023 May;
56(4):154-161.
PMID: 37220781
Introduction: There is a need for novel anxiolytics with improved side effect profiles compared to benzodiazepines. A promising candidate with alternative pharmacodynamics is the translocator protein ligand, etifoxine. Methods: To...
7.
Bader S, Wurfel T, Jahner T, Nothdurfter C, Rupprecht R, Milenkovic V, et al.
Cells
. 2023 Mar;
12(6).
PMID: 36980295
Microglia are the resident immune cells of the central nervous system. Upon stimulus presentation, microglia polarize from a resting to an activated state. Microglial translocator protein 18 kDa (TSPO) is...
8.
Rupprecht R, Pradhan A, Kufner M, Brunner L, Nothdurfter C, Wein S, et al.
Eur Arch Psychiatry Clin Neurosci
. 2022 Dec;
273(7):1477-1487.
PMID: 36574032
There is need for novel fast acting treatment options in affective disorders. 3α-reduced neurosteroids such as allopregnanolone are powerful positive allosteric modulators of GABA receptors and target also extrasynaptic receptors....
9.
Kufner M, Nothdurfter C, Steffling D, Baessler A, Maier L, Qamar Y
Clin Case Rep
. 2022 Sep;
10(9):e6286.
PMID: 36093461
The use of electroconvulsive therapy (ECT) in patients with underlying cardiac disease like hypertrophic cardiomyopathy (HCM) remains without satisfactory clinical guidelines. We provide a case report of successful application of...
10.
Triebelhorn J, Cardon I, Kuffner K, Bader S, Jahner T, Meindl K, et al.
Mol Psychiatry
. 2022 Jun;
29(5):1217-1227.
PMID: 35732695
The molecular pathomechanisms of major depressive disorder (MDD) are still not completely understood. Here, we follow the hypothesis, that mitochondria dysfunction which is inevitably associated with bioenergetic disbalance is a...