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Caroline H Williams-Gray

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Articles 109
Citations 4875
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Recent Articles
1.
Tan M, Iwaki H, Bandres-Ciga S, Sosero Y, Shoai M, Brockmann K, et al.
medRxiv . 2025 Feb; PMID: 39974079
Polygenic risk scores (PRS) in Parkinson's disease (PD) are associated with disease risk. Recently, pathway-specific PRS have been created to take advantage of annotations inking variants to biological pathways or...
2.
Murley A, Bowns L, Camacho M, Williams-Gray C, Tsvetanov K, Rittman T, et al.
Alzheimers Dement . 2024 Nov; 21(1):e14377. PMID: 39559925
Background: The history from a relative or caregiver is an important tool for differentiating neurodegenerative disease. We characterized patterns of caregiver questionnaire responses, at diagnosis and follow-up, on the Cambridge...
3.
Lobanova E, Zhang Y, Emin D, Brelstaff J, Kahanawita L, Malpetti M, et al.
Nat Commun . 2024 Nov; 15(1):9690. PMID: 39528447
Immunotherapeutic strategies for Alzheimer's and Parkinson's disease would be facilitated by better measures of inflammation. Here we established an ultra-sensitive single-molecule pull-down immunoassay combined with direct stochastic optical reconstruction microscopy...
4.
Orlando I, Hezemans F, Ye R, Murley A, Holland N, Regenthal R, et al.
Brain Commun . 2024 Oct; 6(5):fcae297. PMID: 39464213
Noradrenaline is a powerful modulator of cognitive processes, including action decisions underlying saccadic control. Changes in saccadic eye movements are common across neurodegenerative diseases of ageing, including Parkinson's disease. With...
5.
Ribeiro J, Camacho M, Scott K, Greenland J, Evans J, Breen D, et al.
Mov Disord Clin Pract . 2024 Sep; 11(11):1441-1444. PMID: 39344276
Background: A simple prognostic model was previously developed to predict the probability of recently-diagnosed patients reaching negative outcomes (postural instability, dementia or death) in a 5-year period. Objectives: To validate...
6.
Patel B, Greenland J, Williams-Gray C
J Parkinsons Dis . 2024 Sep; 14(7):1283-1300. PMID: 39331111
Inflammation and immune dysregulation have been linked to the pathogenesis and progression of Parkinson's disease (PD), and represent an attractive target for therapeutic intervention, given the potential for repurposing of...
7.
Pourzinal D, Lawson R, Yarnall A, Williams-Gray C, Barker R, Yang J, et al.
Alzheimers Dement (Amst) . 2024 Aug; 16(3):e12625. PMID: 39104403
Introduction: A subset of people with Parkinson's disease (PD) develop dementia faster than others. We aimed to profile PD cognitive subtypes at risk of dementia based on their rate of...
8.
Zhang Y, Lobanova E, Dworkin A, Furlepa M, Yang W, Burke M, et al.
ACS Appl Mater Interfaces . 2024 Jul; 16(28):37255-37264. PMID: 38979642
Preventing nonspecific binding is essential for sensitive surface-based quantitative single-molecule microscopy. Here we report a much-simplified RainX-F127 (RF-127) surface with improved passivation. This surface achieves up to 100-fold less nonspecific...
9.
Furlepa M, Zhang Y, Lobanova E, Kahanawita L, Vivacqua G, Williams-Gray C, et al.
Brain Commun . 2024 Jun; 6(3):fcae178. PMID: 38863577
Saliva is a convenient and accessible biofluid that has potential as a future diagnostic tool for Parkinson's disease. Candidate diagnostic tests for Parkinson's disease to date have predominantly focused on...
10.
Tan M, Lawton M, Pollard M, Brown E, Real R, Carrasco A, et al.
NPJ Parkinsons Dis . 2024 Jun; 10(1):113. PMID: 38849413
There are 90 independent genome-wide significant genetic risk variants for Parkinson's disease (PD) but currently only five nominated loci for PD progression. The biology of PD progression is likely to...