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Caroline Constant

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Articles 27
Citations 81
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Recent Articles
1.
Siverino C, Gens L, Buchholz T, Constant C, Ernst M, Gehweiler D, et al.
NPJ Biofilms Microbiomes . 2025 Feb; 11(1):35. PMID: 39994236
The management of fracture-related infection (FRI) with Debridement, Antibiotics, Irrigation, and Implant Retention (DAIR) is an appealing option, but its suitability is restricted to a relatively narrow proportion of patients....
2.
Marchionatti E, Constant C, Steiner A
Front Vet Sci . 2024 Dec; 11:1446649. PMID: 39711800
Background: Surgical site infections (SSI) following clean abdominal surgery in cattle pose significant economic and welfare concerns. Preoperative skin asepsis aims to minimize microbial load over the surgical field before...
3.
Chen B, Ponce Benavente L, Chitto M, Post V, Constant C, Zeiter S, et al.
NPJ Biofilms Microbiomes . 2024 Aug; 10(1):77. PMID: 39209878
Fracture-related infections (FRIs), particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA), are challenging to treat. This study designed and evaluated a hydrogel loaded with a cocktail of bacteriophages and vancomycin...
4.
Heumann M, Benneker L, Constant C, Ernst M, Richards R, Wilke H, et al.
J Biomech . 2024 Jan; 163:111929. PMID: 38218695
Reliable and timely assessment of bone union between vertebrae is considered a key challenge after spinal fusion surgery. Recently, a novel sensor concept demonstrated the ability to objectively assess posterolateral...
5.
Panebianco C, Constant C, Vernengo A, Nehrbass D, Gehweiler D, DiStefano T, et al.
JOR Spine . 2023 Dec; 6(4):e1293. PMID: 38156055
Background: Intervertebral disc (IVD) disorders (e.g., herniation) directly contribute to back pain, which is a leading cause of global disability. Next-generation treatments for IVD herniation need advanced preclinical testing to...
6.
Chen B, Ponce Benavente L, Chitto M, Wychowaniec J, Post V, DEste M, et al.
J Control Release . 2023 Oct; 364:159-173. PMID: 37866403
Bacteriophage (phage) therapy has shown promise in treating fracture-related infection (FRI); however, questions remain regarding phage efficacy against biofilms, phage-antibiotic interaction, administration routes and dosing, and the development of phage...
7.
Constant C, Aubin C, Kremers H, Garcia D, Wyles C, Rouzrokh P, et al.
N Am Spine Soc J . 2023 Aug; 15:100236. PMID: 37599816
Background: Artificial intelligence is a revolutionary technology that promises to assist clinicians in improving patient care. In radiology, deep learning (DL) is widely used in clinical decision aids due to...
8.
Barcik J, Ernst M, Buchholz T, Constant C, Mys K, Epari D, et al.
Bone . 2023 Jun; 175:116834. PMID: 37385428
Aim: Secondary bone healing requires an adequate level of mechanical stimulation expressed by the extent of interfragmentary motion in the fracture. However, there is no consensus about when the mechanical...
9.
Constant C, Marchionatti E, Desrochers A, Babkine M, Nichols S
J Am Vet Med Assoc . 2022 Nov; 261(2):273-280. PMID: 36434763
Objective: To determine the prognostic value of lactate concentration measurements at admission in cattle with long-bone fractures. Animals: 43 cattle with long-bone fractures between July 2016 and Dec 2018. Procedures:...
10.
Constant C, Stroncek J, Zeiter S, Arens D, Nehrbass D, Gehweiler D, et al.
Eur Spine J . 2022 Aug; 31(10):2812-2821. PMID: 35976438
Purpose: Implant leakage is the most common complication of vertebral augmentation. Alternative injectable materials must demonstrate intravascular safety comparable to or better than polymethyl methacrylate (PMMA). This study assessed the...