Caroline C Ignacio
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Explore the profile of Caroline C Ignacio including associated specialties, affiliations and a list of published articles.
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16
Citations
811
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Recent Articles
1.
Vargas-Meneses M, Massanella M, Ignacio C, Gianella S
Bio Protoc
. 2016 Jul;
5(9).
PMID: 27376109
Multiple viruses can co-infect the genital tract, modifying the immunologic and virologic milieu and possibly playing a role in viral transmission and pathogenesis. The aim of our studies has been...
2.
Hightower G, Wong J, Letendre S, Umlauf A, Ellis R, Ignacio C, et al.
Virology
. 2012 Sep;
433(2):498-505.
PMID: 22999095
Standard methods used to estimate HIV-1 population diversity are often resource intensive (e.g., single genome amplification, clonal amplification and pyrosequencing) and not well suited for large study cohorts. Additional approaches...
3.
Tilghman M, May S, Perez-Santiago J, Ignacio C, Little S, Richman D, et al.
PLoS One
. 2012 May;
7(4):e35401.
PMID: 22563383
Background: To develop a low cost method to screen for virologic failure of antiretroviral therapy (ART) and HIV-1 drug resistance, we performed a retrospective evaluation of a screening assay using...
4.
Wong J, Strain M, Porrata R, Reay E, Sankaran-Walters S, Ignacio C, et al.
PLoS Pathog
. 2010 Feb;
6(1):e1000748.
PMID: 20126442
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamics during antiretroviral...
5.
Hightower G, Letendre S, Cherner M, Gibson S, Ellis R, Wolfson T, et al.
Virology
. 2009 Sep;
394(2):243-8.
PMID: 19762060
Background: When antiretroviral therapy does not fully suppress HIV replication, suboptimal levels of antiretrovirals can select for antiretroviral resistant variants of HIV. These variants may exhibit reduced replication capacity and...
6.
Smith D, May S, Perez-Santiago J, Strain M, Ignacio C, Haubrich R, et al.
AIDS
. 2009 Sep;
23(16):2151-8.
PMID: 19730348
Background: To develop less costly methods to virologically monitor patients receiving antiretroviral therapy, we evaluated methods that use pooled blood samples and quantitative information available from viral load assays to...
7.
Little S, Frost S, Wong J, Smith D, Kosakovsky Pond S, Ignacio C, et al.
J Virol
. 2008 Mar;
82(11):5510-8.
PMID: 18353964
Following interruption of antiretroviral therapy among individuals with acquired drug resistance, preexisting drug-sensitive virus emerges relatively rapidly. In contrast, wild-type virus is not archived in individuals infected with drug-resistant human...
8.
Koelsch K, Liu L, Haubrich R, May S, Havlir D, Gunthard H, et al.
J Infect Dis
. 2008 Feb;
197(3):411-9.
PMID: 18248304
Background: In patients infected with human immunodeficiency virus type 1 (HIV-1), HIV-1 DNA persists during highly active antiretroviral treatment, reflecting long-lived cellular reservoirs of HIV-1. Recent studies report an association...
9.
Smith D, Wong J, Shao H, Hightower G, Mai S, Moreno J, et al.
J Infect Dis
. 2007 Jun;
196(3):356-60.
PMID: 17597449
Background: Transmitted drug-resistant HIV slowly reverts in the blood to drug-sensitive virus. The environment of the male genital tract (MGT) may result in even slower rates of reversion to drug...
10.
Goicoechea M, Smith D, Liu L, May S, Tenorio A, Ignacio C, et al.
J Infect Dis
. 2006 Jun;
194(1):29-37.
PMID: 16741879
Background: Suboptimal CD4+ T cell recovery during antiretroviral therapy (ART) is a common clinical dilemma. Methods: We analyzed viral and immunologic predictors of CD4+ T cell recovery in 116 human...