Carol Ware
Overview
Explore the profile of Carol Ware including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
1339
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0
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Recent Articles
1.
Bomsztyk K, Mar D, Wang Y, Denisenko O, Ware C, Frazar C, et al.
Nucleic Acids Res
. 2019 Mar;
47(12):e69.
PMID: 30927002
Chromatin immunoprecipitation (ChIP) is the most widely used approach for identification of genome-associated proteins and their modifications. We have previously introduced a microplate-based ChIP platform, Matrix ChIP, where the entire...
2.
Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, et al.
Cell Cycle
. 2018 Feb;
17(5):535-549.
PMID: 29466914
To easily edit the genome of naïve human embryonic stem cells (hESC), we introduced a dual cassette encoding an inducible Cas9 into the AAVS1 site of naïve hESC (iCas9). The...
3.
Mathieu J, Zhang Z, Nelson A, Lamba D, Reh T, Ware C, et al.
Stem Cells
. 2013 Jun;
31(9):1737-48.
PMID: 23765801
Adult stem cells reside in hypoxic niches, and embryonic stem cells (ESCs) are derived from a low oxygen environment. However, it is not clear whether hypoxia is critical for stem...
4.
Yu D, Ware C, Waterland R, Zhang J, Chen M, Gadkari M, et al.
Mol Cell Biol
. 2013 Mar;
33(9):1845-58.
PMID: 23459939
During development, a small but significant number of CpG islands (CGIs) become methylated. The timing of developmentally programmed CGI methylation and associated mechanisms of transcriptional regulation during cellular differentiation, however,...
5.
Maggio-Price L, Seamons A, Bielefeldt-Ohmann H, Zeng W, Brabb T, Ware C, et al.
Inflamm Bowel Dis
. 2012 May;
19(1):174-84.
PMID: 22619032
Background: Inflammatory bowel disease (IBD) pathogenesis involves an inadequately controlled immune reaction to intestinal microbiota, and CD4(+) T cells, dependent on MHC class II (MHC-II) processing and presentation by antigen-presenting...
6.
Zhou W, Choi M, Margineantu D, Margaretha L, Hesson J, Cavanaugh C, et al.
EMBO J
. 2012 Mar;
31(9):2103-16.
PMID: 22446391
The function of metabolic state in stemness is poorly understood. Mouse embryonic stem cells (ESC) and epiblast stem cells (EpiSC) are at distinct pluripotent states representing the inner cell mass...
7.
Mathieu J, Zhang Z, Zhou W, Wang A, Heddleston J, Pinna C, et al.
Cancer Res
. 2011 Jun;
71(13):4640-52.
PMID: 21712410
Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors...
8.
Khan I, Hirata R, Wang P, Li Y, Kho J, Nelson A, et al.
Mol Ther
. 2010 Apr;
18(6):1192-9.
PMID: 20407427
Precise genetic manipulation of human pluripotent stem cells will be required to realize their scientific and therapeutic potential. Here, we show that adeno-associated virus (AAV) gene targeting vectors can be...
9.
Stadler B, Ivanovska I, Mehta K, Song S, Nelson A, Tan Y, et al.
Stem Cells Dev
. 2010 Feb;
19(7):935-50.
PMID: 20128659
Studies of embryonic stem cells (ESCs) reveal that these cell lines can be derived from differing stages of embryonic development. We analyzed common changes in the expression of microRNAs (miRNAs)...
10.
Qi J, Yu J, Shcherbata H, Mathieu J, Wang A, Seal S, et al.
Cell Cycle
. 2009 Oct;
8(22):3729-41.
PMID: 19823043
microRNAs (miRNAs) regulate numerous physiological processes such as cell division and differentiation in many tissue types including stem cells. To probe the role that miRNAs play in regulating processes relevant...