Carmine Settembre
Overview
Explore the profile of Carmine Settembre including associated specialties, affiliations and a list of published articles.
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Articles
71
Citations
14309
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Recent Articles
1.
Chiarelli N, Cinquina V, Zoppi N, Bertini V, Maddaluno M, De Leonibus C, et al.
Biomedicines
. 2025 Jan;
12(12.
PMID: 39767655
: Dominant mutations in are known to cause vascular Ehlers-Danlos syndrome (vEDS) by impairing extracellular matrix (ECM) homeostasis. This disruption leads to the fragility of soft connective tissues and a...
2.
Maddaluno M, Settembre C
Science
. 2024 Aug;
385(6712):930-931.
PMID: 39208121
Oxidative damage triggers micronuclear membrane rupture and defective repair.
3.
De Leonibus C, Maddaluno M, Ferriero R, Besio R, Cinque L, Lim P, et al.
Dev Cell
. 2024 Aug;
59(16):2035-2052.e10.
PMID: 39094564
Protein biogenesis within the endoplasmic reticulum (ER) is crucial for organismal function. Errors during protein folding necessitate the removal of faulty products. ER-associated protein degradation and ER-phagy target misfolded proteins...
4.
Iavarone F, Zaninello M, Perrone M, Monaco M, Barth E, Gaedke F, et al.
EMBO Rep
. 2024 Jul;
25(8):3651-3677.
PMID: 39039299
Endoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including...
5.
Settembre C, Perera R
Nat Rev Mol Cell Biol
. 2023 Nov;
25(3):223-245.
PMID: 38001393
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdown to coordinate programmes for growth, repair and stress adaptation. The lysosome orchestrates these key functions...
6.
Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf M, Chamoli M, et al.
Science
. 2023 Jun;
380(6649):eabn9257.
PMID: 37289866
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and...
7.
Russo S, Scotto di Carlo F, Maurizi A, Fortunato G, Teti A, Licastro D, et al.
Bone Res
. 2023 Mar;
11(1):16.
PMID: 36918542
Paget's disease (PDB) is a late-onset bone remodeling disorder with a broad spectrum of symptoms and complications. One of the most aggressive forms is caused by the P937R mutation in...
8.
Di Lorenzo G, Iavarone F, Maddaluno M, Plata-Gomez A, Aureli S, Quezada Meza C, et al.
Sci Adv
. 2022 Aug;
8(35):eabo1215.
PMID: 36044577
Selective degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is initiated by ER-phagy receptors, which facilitate the incorporation of ER fragments into autophagosomes. FAM134 reticulon family proteins (FAM134A, FAM134B,...
9.
Akwa Y, Di Malta C, Zallo F, Gondard E, Lunati A, Diaz-de-Grenu L, et al.
Autophagy
. 2022 Jul;
19(2):660-677.
PMID: 35867714
Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be...
10.
Franci L, Tubita A, Bertolino F, Palma A, Cannino G, Settembre C, et al.
Aging Cell
. 2022 Jun;
21(7):e13620.
PMID: 35642724
Mitochondria are the major source of reactive oxygen species (ROS), whose aberrant production by dysfunctional mitochondria leads to oxidative stress, thus contributing to aging as well as neurodegenerative disorders and...