Carlos A Zarate
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Explore the profile of Carlos A Zarate including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Quintanilla B, Greenstein D, Tripathi A, Bartosh A, Yuan P, Zarate C, et al.
Brain Behav Immun
. 2025 Mar;
PMID: 40064429
Recent evidence suggests that the rapid-acting antidepressant ketamine has immune regulatory functions. The complement system is an important component of the innate immune response and plays a key role in...
2.
Wilkinson S, Bryan C, Alphs L, Canuso C, Ostacher M, Price R, et al.
JAMA Psychiatry
. 2025 Feb;
PMID: 39937491
Importance: Suicide is a public health crisis, and despite renewed efforts to confront this problem, suicide rates continue to rise in the US. While suicide prevention encompasses a broad array...
3.
van Velzen L, Colic L, Ceja Z, Dauvermann M, Villa L, Savage H, et al.
medRxiv
. 2025 Jan;
PMID: 39802789
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent....
4.
Ketamine and Hydroxynorketamine as Novel Pharmacotherapies for the Treatment of Opioid Use Disorders
Onisiforou A, Michael A, Apostolakis M, Mammadov E, Mitka A, Kalatta M, et al.
Biol Psychiatry
. 2024 Sep;
97(6):563-579.
PMID: 39293647
Opioid use disorder (OUD) has reached epidemic proportions, with many countries facing high levels of opioid use and related fatalities. Although currently prescribed medications for OUD are considered lifesaving, they...
5.
Hess E, Greenstein D, Hutchinson O, Zarate C, Gould T
Am J Psychiatry
. 2024 Jul;
181(9):815-823.
PMID: 38982828
Objective: The authors sought to assess the prosocial, entactogen effects of ketamine. Methods: Pleasure from social situations was assessed in a sample of participants with treatment-resistant depression from randomized, double-blind,...
6.
Jones G, Vecera C, Ruiz A, Wu H, McInturff S, Orejarena M, et al.
J Clin Psychiatry
. 2024 May;
85(2).
PMID: 38696221
Although individuals with a family history of alcohol use disorder (AUD) have a superior antidepressant response to ketamine, outcomes in patients with current AUD remain unclear. This study sought to...
7.
Lucantonio F, Li S, Lu J, Roeglin J, Bontempi L, Shields B, et al.
bioRxiv
. 2023 Jun;
PMID: 37333325
Ketamine's role in providing a rapid and sustained antidepressant response, particularly for patients unresponsive to conventional treatments, is increasingly recognized. A core symptom of depression, anhedonia, or the loss of...
8.
Campos A, van Velzen L, Veltman D, Pozzi E, Ambrogi S, Ballard E, et al.
Neuropsychology
. 2023 Apr;
37(3):315-329.
PMID: 37011159
Objective: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across...
9.
Bloomfield-Clagett B, Ballard E, Greenstein D, Wilkinson S, Grunebaum M, Murrough J, et al.
Int J Neuropsychopharmacol
. 2022 Aug;
25(10):827-838.
PMID: 35994774
Background: Clinical trials of intravenous (IV) racemic (R,S)-ketamine (hereafter referred to as IV ketamine) have consistently reported rapid and substantial reductions in overall depressive symptoms compared with saline (inactive placebo)...
10.
Wulf H, Browne C, Zarate C, Lucki I
Psychopharmacology (Berl)
. 2022 Apr;
239(7):2309-2316.
PMID: 35459958
Emerging evidence has implicated the endogenous opioid system in mediating ketamine's antidepressant activity in subjects with major depressive disorder. To date, mu opioid receptors have been suggested as the primary...