Carlos-Alberto Goncalves
Overview
Explore the profile of Carlos-Alberto Goncalves including associated specialties, affiliations and a list of published articles.
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Articles
157
Citations
2269
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Recent Articles
1.
Brezolin E, Gayger-Dias V, Da Silva V, Cigerce A, Schultz B, Sobottka T, et al.
J Alzheimers Dis Rep
. 2025 Mar;
8(1):1381-1393.
PMID: 40034350
Background: In the sporadic model of Alzheimer's disease (AD), induced by intracerebroventricular streptozotocin (STZ) administration, cognitive impairment is accompanied by specific astrocytic changes in the hippocampus prior to amyloid deposition....
2.
Schmitz I, Bobermin L, da Silva A, Weber F, Thomaz N, Schmitz F, et al.
Pharmacol Rep
. 2025 Feb;
PMID: 39982625
Background: Haloperidol is a widely used antipsychotic for the treatment of neuropsychiatric disorders, the pathophysiology of which may involve hippocampal alterations. Hippocampus is affected by long-term use of the drug,...
3.
Quincozes-Santos A, Bobermin L, Tramontina A, Wartchow K, Da Silva V, Gayger-Dias V, et al.
Neurotox Res
. 2025 Jan;
43(1):7.
PMID: 39869271
Resveratrol, a natural polyphenol, has shown promising neuroprotective effects in several in vivo and in vitro experimental models. However, the mechanisms by which resveratrol mediates these effects are not fully...
4.
Thomaz N, Bobermin L, Sesterheim P, Varela A, Fumaco T, Seady M, et al.
J Neurovirol
. 2024 Dec;
PMID: 39625558
Zika virus (ZIKV) is a neurotropic flavivirus that induces congenital Zika syndrome and neurodevelopmental disorders. Given that ZIKV can infect and replicate in neural cells, neurological complications in adult brain...
5.
Vizuete A, Froes F, Seady M, Caurio A, Ramires Junior O, Leite A, et al.
Brain Behav Immun Health
. 2024 Nov;
42:100901.
PMID: 39583162
Neuroinflammation is a pathophysiological feature of numerous neurological and psychiatric disorders. The immune response in the central nervous system, driven by microglia and astrocytes, leads to metabolic reprogramming towards aerobic...
6.
da Silva A, Bobermin L, Santos C, de Souza Almeida R, Lissner L, Dos Santos T, et al.
Neurochem Res
. 2024 Nov;
50(1):22.
PMID: 39560678
Antipsychotics are drugs commonly prescribed to treat a variety of psychiatric conditions. They are classified as typical and atypical, depending on their affinity for dopaminergic and serotonergic receptors. Although neurons...
7.
Seady M, Schirmbeck G, Taday J, Froes F, Bau J, Jantsch J, et al.
J Nutr Biochem
. 2024 Sep;
135:109768.
PMID: 39278425
Inflammation is a common feature of neurological disorders that alters cell function in microglia and astrocytes as well as other neuronal cell types. Astrocytes modulate blood flow, regulate glutamate metabolism,...
8.
Gayger-Dias V, Menezes L, Da Silva V, Stiborski A, Silva A, Sobottka T, et al.
Neurochem Res
. 2024 May;
49(7):1851-1862.
PMID: 38733521
Alzheimer's disease (AD) is an age-dependent neurodegenerative disease that is typically sporadic and has a high social and economic cost. We utilized the intracerebroventricular administration of streptozotocin (STZ), an established...
9.
Vizuete A, Goncalves C
Neurochem Res
. 2024 May;
49(7):1823-1837.
PMID: 38727985
Methylglyoxal (MG) is considered a classical biomarker of diabetes mellitus and its comorbidities. However, a role for this compound in exacerbated immune responses, such as septicemia, is being increasingly observed...
10.
Bobermin L, da Costa D, de Moraes A, da Silva V, de Oliveira G, Sesterheim P, et al.
Biochimie
. 2024 Apr;
223:196-205.
PMID: 38642825
Astrocytes are glial cells that play key roles in neuroinflammation, which is a common feature in diabetic encephalopathy and aging process. Metformin is an antidiabetic compound that shows neuroprotective properties,...