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Carl L Faingold

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Recent Articles
1.
Guo J, Min D, Farrell E, Zhou Y, Faingold C, Cotten J, et al.
Epilepsia . 2024 Apr; 65(6):1791-1800. PMID: 38593237
Objective: Sudden unexpected death in epilepsy (SUDEP) is an underestimated complication of epilepsy. Previous studies have demonstrated that enhancement of serotonergic neurotransmission suppresses seizure-induced sudden death in evoked seizure models....
2.
Faingold C, Feng H
Epilepsia . 2023 Jun; 64(9):2256-2259. PMID: 37386865
In response to the comments by Singh and colleagues about our recent paper proposing a unified hypothesis of SUDEP, we definitely agree that more research is needed. This research should...
3.
Faingold C, Feng H
Epilepsia . 2023 Jan; 64(4):779-796. PMID: 36715572
Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in people with epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of terminal...
4.
Tupal S, Faingold C
Epilepsy Res . 2021 Oct; 177:106777. PMID: 34601387
Rationale: Our previous study showed that the recently approved anticonvulsant drug, fenfluramine, which enhances the release of serotonin (5-hydroxytryptamine, 5-HT) in the brain, prevents seizure-induced respiratory arrest (S-IRA) in the...
5.
Schilling W, McGrath M, Yang T, Glazebrook P, Faingold C, Kunze D
PLoS One . 2019 Oct; 14(10):e0223468. PMID: 31634345
This study was designed to evaluate cardiac and respiratory dysfunction in a mouse model of sudden unexpected death in epilepsy i.e., SUDEP. We simultaneously monitored respiration via plethysmography and the...
6.
Murugesan A, Rani M, Vilella L, Lacuey N, Hampson J, Faingold C, et al.
Neurology . 2019 Sep; 93(15):e1485-e1494. PMID: 31484709
Objective: To determine the relationship between serum serotonin (5-HT) levels, ictal central apnea (ICA), and postconvulsive central apnea (PCCA) in epileptic seizures. Methods: We prospectively evaluated video EEG, plethysmography, capillary...
7.
White P, Faingold C
Case Rep Crit Care . 2019 Aug; 2019:3925438. PMID: 31467729
We present a case of serious antidepressant discontinuation syndrome (ADDS) in a 72- year-old woman in the intensive care unit (ICU). Although this syndrome may be mild under ambulatory conditions,...
8.
Kommajosyula S, Faingold C
Epilepsia . 2019 May; 60(6):1221-1233. PMID: 31056750
Objective: Sudden unexpected death in epilepsy (SUDEP) is a critical issue in epilepsy, and DBA/1 mice are a useful animal model of this devastating epilepsy sequela. The serotonin hypothesis for...
9.
Tupal S, Faingold C
Epilepsia . 2019 Feb; 60(3):485-494. PMID: 30719703
Objective: Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure-induced death in...
10.
Kommajosyula S, Tupal S, Faingold C
Epilepsy Res . 2018 Aug; 147:1-8. PMID: 30165263
Post-ictal cardiorespiratory failure is implicated as a major cause of sudden unexpected death in epilepsy (SUDEP) in patients. The DBA/1 mouse model of SUDEP is abnormally susceptible to fatal seizure-induced...