Carl Hobbs
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Explore the profile of Carl Hobbs including associated specialties, affiliations and a list of published articles.
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64
Citations
1902
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Recent Articles
1.
Goncalves M, Wu Y, Clarke E, Grist J, Moehlin J, Mendoza-Parra M, et al.
Front Mol Neurosci
. 2024 Sep;
17:1411384.
PMID: 39228795
Retinoic acid receptor β2 (RARβ2) is an emerging therapeutic target for spinal cord injuries (SCIs) with a unique multimodal regenerative effect. We have developed a first-in-class RARβ agonist drug, C286,...
2.
Karpov M, Hobbs C, Jayasinghe S, Sturzenbaum S
Biochem Biophys Res Commun
. 2024 Mar;
709:149827.
PMID: 38554600
This study explored the uptake of lead in the epigeic earthworm Dendrobaena veneta exposed to 0, 1000, and 2500 μg Pb/g soil. The soil metal content was extracted using strong...
3.
Chauhan J, Grandits M, Palhares L, Mele S, Nakamura M, Lopez-Abente J, et al.
Nat Commun
. 2023 May;
14(1):2192.
PMID: 37185332
Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effective...
4.
Buhidma Y, Hobbs C, Malcangio M, Duty S
NPJ Parkinsons Dis
. 2023 Apr;
9(1):69.
PMID: 37100804
Pain is a key non-motor feature of Parkinson's disease (PD) that significantly impacts on life quality. The mechanisms underlying chronic pain in PD are poorly understood, hence the lack of...
5.
Hobbs C, Formstone C
Wellcome Open Res
. 2023 Mar;
7:138.
PMID: 36938121
Complex organ formation requires the coordinated morphogenesis of adjacent tissue layers. Here, we report a role for the planar cell polarity (PCP) proteins Fz6 and Celsr1 in generating squamous basal...
6.
Brown S, Malik S, Aljammal M, OFlynn A, Hobbs C, Shah M, et al.
JBMR Plus
. 2023 Feb;
7(2):e10707.
PMID: 36751415
The identity of the cells that form the periosteum during development is controversial with current dogma suggesting these are derived from a Sox9-positive progenitor. Herein, we characterize a newly created...
7.
Parisi C, Salvatore L, Veschini L, Serra M, Hobbs C, Madaghiele M, et al.
J Tissue Eng
. 2022 Jan;
11:2041731419896068.
PMID: 35003613
Osteochondral defects remain a major clinical challenge mainly due to the combined damage to the articular cartilage and the underlying bone, and the interface between the two tissues having very...
8.
Vinsland E, Baskaran P, Mihaylov S, Hobbs C, Wood H, Bouybayoune I, et al.
Sci Rep
. 2021 Aug;
11(1):16299.
PMID: 34381067
Correct orchestration of nervous system development is a profound challenge that involves coordination of complex molecular and cellular processes. Mechanistic target of rapamycin (mTOR) signaling is a key regulator of...
9.
Barallobre-Barreiro J, Woods E, Bell R, Easton J, Hobbs C, Eager M, et al.
Matrix Biol Plus
. 2021 Feb;
4:100016.
PMID: 33543013
Following wound damage to the skin, the scarring spectrum is wide-ranging, from a manageable normal scar through to pathological keloids. The question remains whether these fibrotic lesions represent simply a...
10.
Strotton M, Bodey A, Wanelik K, Hobbs C, Rau C, Bradbury E
Exp Neurol
. 2020 Nov;
336:113529.
PMID: 33220238
Extensive structural changes occur within the spinal cord following traumatic injury. Acute tissue debris and necrotic tissue are broken down, proliferating local glia and infiltrating leukocytes remodel tissue biochemical and...