Carine Legrand
Overview
Explore the profile of Carine Legrand including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
364
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Recent Articles
1.
Legrand C, Andriantsoa R, Lichter P, Raddatz G, Lyko F
PLoS Genet
. 2023 Dec;
19(12):e1011085.
PMID: 38096267
Clonal genome evolution is a key feature of asexually reproducing species and human cancer development. While many studies have described the landscapes of clonal genome evolution in cancer, few determine...
2.
Li W, Mirone J, Prasad A, Miolane N, Legrand C, Dao Duc K
Front Bioinform
. 2023 Aug;
3:1211819.
PMID: 37637212
Conventional dimensionality reduction methods like Multidimensional Scaling (MDS) are sensitive to the presence of orthogonal outliers, leading to significant defects in the embedding. We introduce a robust MDS method, called...
3.
Cirzi C, Dyckow J, Legrand C, Schott J, Guo W, Perez Hernandez D, et al.
EMBO J
. 2023 Aug;
42(19):e112507.
PMID: 37609797
Queuosine (Q) is a modified nucleoside at the wobble position of specific tRNAs. In mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is introduced into tRNA...
4.
Legrand C, Dao Duc K, Tuorto F
Methods Mol Biol
. 2022 Feb;
2428:133-156.
PMID: 35171478
Ribosome profiling methods are based on high-throughput sequencing of ribosome-protected mRNA footprints and allow to study in detail translational changes. Bioinformatic and statistical tools are necessary to analyze sequencing data....
5.
6.
Maiakovska O, Andriantsoa R, Tonges S, Legrand C, Gutekunst J, Hanna K, et al.
Commun Biol
. 2021 Jan;
4(1):74.
PMID: 33462402
The marbled crayfish (Procambarus virginalis) represents a very recently evolved parthenogenetic freshwater crayfish species that has invaded diverse habitats in Europe and in Madagascar. However, population genetic analyses have been...
7.
Navarro I, Tuorto F, Jordan D, Legrand C, Price J, Braukmann F, et al.
EMBO J
. 2020 Dec;
40(6):e105496.
PMID: 33283887
Methylation of carbon-5 of cytosines (m C) is a post-transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m C-methyltransferases have been studied, the impact of...
8.
Legrand C, Tuorto F
Nucleic Acids Res
. 2019 Nov;
48(2):e7.
PMID: 31777932
Recently, newly developed ribosome profiling methods based on high-throughput sequencing of ribosome-protected mRNA footprints allow to study genome-wide translational changes in detail. However, computational analysis of the sequencing data still...
9.
Muller M, Legrand C, Tuorto F, Kelly V, Atlasi Y, Lyko F, et al.
Nucleic Acids Res
. 2019 Feb;
47(7):3711-3727.
PMID: 30715423
In eukaryotes, the wobble position of tRNA with a GUN anticodon is modified to the 7-deaza-guanosine derivative queuosine (Q34), but the original source of Q is bacterial, since Q is...
10.
Muller M, Samel-Pommerencke A, Legrand C, Tuorto F, Lyko F, Ehrenhofer-Murray A
RNA Biol
. 2019 Jan;
16(3):249-256.
PMID: 30646830
Enzymes of the cytosine-5 RNA methyltransferase Trm4/NSun2 family methylate tRNAs at C48 and C49 in multiple tRNAs, as well as C34 and C40 in selected tRNAs. In contrast to most...