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Cameron Bruggeman

Explore the profile of Cameron Bruggeman including associated specialties, affiliations and a list of published articles. Areas
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Citations 6669
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Recent Articles
1.
Rizvi N, Hellmann M, Snyder A, Kvistborg P, Makarov V, Havel J, et al.
Science . 2015 Mar; 348(6230):124-8. PMID: 25765070
Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are revolutionizing cancer treatment. To unravel the genomic determinants of response to this therapy, we used whole-exome...
2.
Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky J, Desrichard A, et al.
N Engl J Med . 2014 Nov; 371(23):2189-2199. PMID: 25409260
Background: Immune checkpoint inhibitors are effective cancer treatments, but molecular determinants of clinical benefit are unknown. Ipilimumab and tremelimumab are antibodies against cytotoxic T-lymphocyte antigen 4 (CTLA-4). Anti-CTLA-4 treatment prolongs...