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C Yap

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Articles 35
Citations 359
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Recent Articles
1.
Westphalen C, Martins-Branco D, Beal J, Cardone C, Coleman N, Schram A, et al.
Ann Oncol . 2024 Aug; 35(11):936-953. PMID: 39187421
Background: Advances in precision oncology led to approval of tumour-agnostic molecularly guided treatment options (MGTOs). The minimum requirements for claiming tumour-agnostic potential remain elusive. Methods: The European Society for Medical...
2.
Alger E, Lee S, Cheung Y, Yap C
ESMO Open . 2024 Jul; 9(7):103626. PMID: 38968929
Background: Determining the maximum tolerated dose (MTD) remains the primary objective for the majority of dose-finding oncology trials. Whilst MTD determination often relies upon clinicians to identify dose-limiting toxicities (DLTs)...
3.
Villacampa G, Dennett S, Mello E, Holton J, Lai X, Kilburn L, et al.
ESMO Open . 2024 Jun; 9(7):103603. PMID: 38925083
Background: In a competitive landscape with many ongoing adjuvant randomised controlled trials (RCTs), the prevalence of trials that failed to recruit their targeted sample size and were inadequately powered is...
4.
Tang T, Yap C, Chan S, Soon S, Sivanathan C, Gogna A, et al.
Cardiovasc Intervent Radiol . 2024 Jun; 47(7):863-874. PMID: 38898146
Purpose: The aim of PRISTINE was to evaluate the 6 and 12 months safety and efficacy of the Selution Sustained Limus Release (SLR)™ sirolimus-coated balloon for treatment of complex lower...
5.
Tedjawirja V, Mieremet A, Rombouts K, Yap C, Neele A, Northoff B, et al.
PLoS One . 2023 May; 18(5):e0285607. PMID: 37228156
Introduction: Follicle stimulating hormone (FSH) is identified to play a role in postmenopausal disease and hypothesized to affect abdominal aortic aneurysm (AAA) onset/progression in postmenopausal women. We aimed to detect...
6.
Araujo D, Greystoke A, Bates S, Bayle A, Calvo E, Castelo-Branco L, et al.
Ann Oncol . 2022 Oct; 34(1):48-60. PMID: 36182023
In 2021, the Food and Drug Administration Oncology Center of Excellence announced Project Optimus focusing on dose optimization for oncology drugs. The Methodology for the Development of Innovative Cancer Therapies...
7.
Cole M, Yap C, Buckley C, Ng W, McInnes I, Filer A, et al.
Trials . 2021 Jul; 22(1):433. PMID: 34229728
Background: Adaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical complexity but uptake has been slow especially outside of cancer trials. TRAFIC is a...
8.
Basu S, Yap C, Mason S
Occup Med (Lond) . 2016 Nov; 66(9):737-742. PMID: 27852879
Background: Previous work has established that health care staff, in particular emergency department (ED) personnel, experience significant occupational stress but the underlying stressors have not been well quantified. Such data...
9.
King A, Barton D, Beard H, Than N, Moore J, Corbett C, et al.
BMJ Open . 2015 Mar; 5(3):e007700. PMID: 25795699
Introduction: Liver disease mortality and morbidity are rapidly rising and liver transplantation is limited by organ availability. Small scale human studies have shown that stem cell therapy is safe and...
10.
Vickers M, Clayton Z, Yap C, Sloboda D
Endocrinology . 2011 Feb; 152(4):1378-87. PMID: 21303952
The effects of maternal fructose intake on offspring health remain largely unknown, despite the marked increase in consumption of sweetened beverages that has paralleled the obesity epidemic. The present study...