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C Orrell

Explore the profile of C Orrell including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 99
Followers 0
Related Specialties
General Medicine
Public Health
Pharmacology
Top 10 Co-Authors
J A Joska
P A Wilson
N Maxwell
M Tlali
D Egan
M Cornell
J Castillo-Mancilla
A Owen
M Boffito
R Puls
Published In
S Afr Med J
BMC Infect Dis
AIDS Res Ther
Trans R Soc Trop Med Hyg
Epidemiol Psychiatr Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
Singh Y, Castillo-Mancilla J, Madimabe R, Jennings L, Ferraris C, Robbins R, et al.
AIDS Res Ther . 2023 Sep; 20(1):67. PMID: 37705102
Background: Suboptimal antiretroviral (ART) adherence can lead to virologic failure with consequent HIV-1 resistance. Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a powerful biomarker of cumulative adherence, predictive...
2.
ImpACT+, a coping intervention to improve clinical outcomes for women living with HIV and sexual trauma in South Africa: study protocol for a randomized controlled trial
Sikkema K, Rabie S, King A, Watt M, Mulawa M, Andersen L, et al.
Trials . 2022 Aug; 23(1):680. PMID: 35982485
Background: Addressing sexual trauma in the context of HIV care is essential to improve clinical outcomes and mental health among women in South Africa. Women living with HIV (WLH) report...
3.
The treatment gap for mental disorders in adults enrolled in HIV treatment programmes in South Africa: a cohort study using linked electronic health records
Ruffieux Y, Efthimiou O, Van den Heuvel L, Joska J, Cornell M, Seedat S, et al.
Epidemiol Psychiatr Sci . 2021 May; 30:e37. PMID: 33993900
Aims: Mental disorders are common in people living with HIV (PLWH) but often remain untreated. This study aimed to explore the treatment gap for mental disorders in adults followed-up in...
4.
Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa
Bionghi N, Daftary A, Maharaj B, Msibi Z, Amico K, Friedland G, et al.
BMC Infect Dis . 2018 Apr; 18(1):171. PMID: 29642874
Background: The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to prevent amplified...
5.
Pharmacokinetic and Pharmacodynamic Comparison of Once-Daily Efavirenz (400 mg vs. 600 mg) in Treatment-Naïve HIV-Infected Patients: Results of the ENCORE1 Study
Dickinson L, Amin J, Else L, Boffito M, Egan D, Owen A, et al.
Clin Pharmacol Ther . 2015 Jun; 98(4):406-16. PMID: 26044067
Daily efavirenz 400 mg (EFV400) was virologically noninferior to 600 mg (EFV600) at 48 weeks in treatment-naïve patients. We evaluated EFV400 and EFV600 pharmacokinetics (NONMEM v. 7.2), assessing patient demographics...
6.
Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate
Orrell C, Taylor W, Olliaro P
Trans R Soc Trop Med Hyg . 2001 Nov; 95(5):517-8. PMID: 11706664
Combination antimalarial therapy is being explored to delay development of resistance to falciparum malaria. This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2...
7.
Adherence to antiretroviral therapy--achievable in the South African context?
Orrell C, Bekker L, Wood R
S Afr Med J . 2001 Jul; 91(6):483-4. PMID: 11455708
No abstract available.