C McCaig
Overview
Explore the profile of C McCaig including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
255
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Recent Articles
1.
Sahin P, McCaig C, Jeevahan J, Murray J, Hainsworth A
Neuropathol Appl Neurobiol
. 2013 Feb;
39(6):623-33.
PMID: 23363009
Aims: Serum- and glucocorticoid-inducible kinase 1 (SGK1) protects neuronal cells from injury stimuli in vitro, and exerts anti-apoptotic effects via downstream targets including the forkhead-like transcription factor FOXO3a. SGK1 is...
2.
Burrows C, Holly J, Laurence N, Vernon E, Carter J, Clark M, et al.
Endocrinology
. 2006 Apr;
147(7):3484-500.
PMID: 16614079
IGF-binding protein (IGFBP)-3 is generally considered to have actions that counterbalance those of IGFs and is therefore being developed as a cancer treatment. In breast tumors, however, high levels are...
3.
McCaig C, Fowler C, Laurence N, Lai T, Savage P, Holly J, et al.
Br J Cancer
. 2002 Jun;
86(12):1963-9.
PMID: 12085194
In addition to modulating insulin-like growth factors action, it is now clear that insulin-like growth factor-binding protein-3 also has intrinsic effects on cell growth and survival. We have compared the...
4.
Perks C, McCaig C, Clarke J, Clemmons D, Holly J
Biochem Biophys Res Commun
. 2002 Jun;
294(5):995-1000.
PMID: 12074575
We have demonstrated previously that IGFBP-5 alone had no effect on cell death but modulated ceramide-induced apoptosis in Hs578T IGF non-responsive cells. To investigate if IGFBP-5 maintains its intrinsic ability...
5.
Perks C, McCaig C, Clarke J, Clemmons D, Holly J
Biochem Biophys Res Commun
. 2002 Jun;
294(5):988-94.
PMID: 12074574
We demonstrated previously that IGFBP-3 alone had no effect on cell death, but dramatically modulated apoptosis in Hs578T IGF non-responsive cells. We investigated whether a non-IGF binding mutant of IGFBP-3...
6.
Perks C, McCaig C, Holly J
J Cell Biochem
. 2000 Nov;
80(2):248-58.
PMID: 11074596
We have demonstrated previously in Hs578T cells that insulin-like growth factor binding protein (IGFBP)-3 can significantly accentuate ceramide (C2)-induced apoptosis, but has no effect on cell death induced by integrin...
7.
Rajnicek A, McCaig C
J Cell Sci
. 1998 Feb;
110 ( Pt 23):2915-24.
PMID: 9359874
We exploited our observation that embryonic Xenopus spinal neurites align parallel to grooves in a quartz surface and that embryonic rat hippocampal neurites align perpendicular to shallow, narrow grooves (see...
8.
Rajnicek A, Britland S, McCaig C
J Cell Sci
. 1998 Feb;
110 ( Pt 23):2905-13.
PMID: 9359873
We used an in vitro system that eliminates competing guidance cues found in embryos to determine whether substratum topography alone provides important neurite guidance information. Dissociated embryonic Xenopus spinal cord...
9.
Britland S, McCaig C
Exp Cell Res
. 1996 Jul;
226(1):31-8.
PMID: 8660936
Nerve cells detect and respond to multiple extrinsic guidance cues during development and regeneration using a motile growth cone. Navigational decisions may be required of the growth cone when different...
10.