C Matthias Wilk
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Explore the profile of C Matthias Wilk including associated specialties, affiliations and a list of published articles.
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20
Citations
319
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Recent Articles
1.
Belabed M, Park M, Blouin C, Balan S, Moon C, Freed G, et al.
Nat Immunol
. 2025 Jan;
26(2):188-199.
PMID: 39838105
Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity and for promoting immunogenic responses to pathogens and cancer. The subcellular mechanism for cDC maturation remains...
2.
Spencer Chapman M, Wilk C, Boettcher S, Mitchell E, Dawson K, Williams N, et al.
Nature
. 2024 Oct;
635(8040):926-934.
PMID: 39478227
Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those from a donor. Here, to quantify dynamics of long-term stem cell engraftment, we sequenced genomes...
3.
Park M, Le Berichel J, Hamon P, Wilk C, Belabed M, Yatim N, et al.
Science
. 2024 Sep;
386(6720):eadn0327.
PMID: 39236155
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that aging of the immune system, regardless of the...
4.
Cathomas F, Lin H, Chan K, Li L, Parise L, Alvarez J, et al.
Nature
. 2024 Feb;
626(8001):1108-1115.
PMID: 38326622
Psychosocial stress has profound effects on the body, including the immune system and the brain. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations...
5.
Wilk C, Cathomas F, Torok O, Le Berichel J, Park M, Bigenwald C, et al.
Immunity
. 2023 Dec;
56(12):2790-2802.e6.
PMID: 38091952
Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an...
6.
Wilk C, Cathomas F, Torok O, Le Berichel J, Park M, Heaton G, et al.
bioRxiv
. 2023 Oct;
PMID: 37873371
Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an...
7.
Tometten M, Kirschner M, Meyer R, Begemann M, Halfmeyer I, Vieri M, et al.
Hemasphere
. 2023 Apr;
7(5):e874.
PMID: 37096215
Telomere biology disorders (TBD) result from premature telomere shortening due to pathogenic germline variants in telomere maintenance-associated genes. In adults, TBD are characterized by mono/oligosymptomatic clinical manifestations (cryptic TBD) contributing...
8.
Sanchez-Paulete A, Mateus-Tique J, Mollaoglu G, Nielsen S, Marks A, Lakshmi A, et al.
Cancer Immunol Res
. 2022 Sep;
10(11):1354-1369.
PMID: 36095236
Tumor-associated macrophages (TAM) are one of the most abundant cell types in many solid tumors and typically exert protumor effects. This has led to an interest in macrophage-depleting agents for...
9.
Wilk C, Kovtonyuk L, Manz M
Blood Adv
. 2022 Jun;
6(15):4485-4489.
PMID: 35736667
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment approach for certain benign and malignant hematologic diseases. The actual HSCT is preceded by a conditioning therapy that reduces host-vs-HSCT...
10.
Dhainaut M, Rose S, Akturk G, Wroblewska A, Nielsen S, Park E, et al.
Cell
. 2022 Mar;
185(7):1223-1239.e20.
PMID: 35290801
While CRISPR screens are helping uncover genes regulating many cell-intrinsic processes, existing approaches are suboptimal for identifying extracellular gene functions, particularly in the tissue context. Here, we developed an approach...