C M Wilmot
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Explore the profile of C M Wilmot including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
563
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Recent Articles
1.
Wilmot C
Biochem Soc Trans
. 2003 May;
31(Pt 3):493-6.
PMID: 12773142
The process by which molecular oxygen is activated to enable it to function as an electron acceptor in biology is poorly understood. The quinoprotein copper-containing amine oxidase (CuAO) catalyses the...
2.
Pogue B, Pitts J, Mycek M, Sloboda R, Wilmot C, Brandsema J, et al.
Photochem Photobiol
. 2002 Jan;
74(6):817-24.
PMID: 11783938
In this study the endogenous fluorescence signal attributed to reduced nicotinamide adenine dinucleotide (NADH) has been measured in response to photodynamic therapy (PDT)-induced damage. Measurements on cells in vitro have...
3.
Firbank S, Rogers M, Wilmot C, Dooley D, Halcrow M, Knowles P, et al.
Proc Natl Acad Sci U S A
. 2001 Nov;
98(23):12932-7.
PMID: 11698678
Galactose oxidase (EC ) is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehydes. The protein contains an...
4.
Timmins G, Robb F, Wilmot C, Jackson S, Swartz H
J Exp Biol
. 2001 Oct;
204(Pt 16):2795-801.
PMID: 11683435
Although many aspects of firefly bioluminescence are understood, the mechanism by which adult fireflies produce light as discrete rapid flashes is not. Here we examine the most postulated theory, that...
5.
Murray J, Kurtis C, Tambyrajah W, Saysell C, Wilmot C, Parsons M, et al.
Biochemistry
. 2001 Oct;
40(43):12808-18.
PMID: 11669617
Copper amine oxidases are homodimeric enzymes that catalyze two reactions: first, a self-processing reaction to generate the 2,4,5-trihydroxyphenylalanine (TPQ) cofactor from an active site tyrosine by a single turnover mechanism;...
6.
OHara J, Blumenthal R, Grinberg O, Demidenko E, Grinberg S, Wilmot C, et al.
Radiat Res
. 2001 Feb;
155(3):466-73.
PMID: 11182798
The efficacy of radiation treatment depends upon local oxygen concentration. We postulated that the variability in responsiveness of tumor xenografts to a fixed dose of radioimmunotherapy might be related to...
7.
Pogue B, Paulsen K, OHara J, Wilmot C, Swartz H
Radiat Res
. 2000 Dec;
155(1 Pt 1):15-25.
PMID: 11121211
Numerical simulations of oxygen diffusion from the capillaries in tumor tissue were used to predict the capillary oxygen supply within and near hypoxic regions of the RIF-1 tumor. A finite...
8.
Hajdu J, Neutze R, Sjogren T, Edman K, Szoke A, Wilmouth R, et al.
Nat Struct Biol
. 2000 Nov;
7(11):1006-12.
PMID: 11062553
Time-resolved structural studies on biomolecular function are coming of age. Focus has shifted from studies on 'systems of opportunities' to a more problem-oriented approach, addressing significant questions in biology and...
9.
Wilmot C, Hajdu J, McPherson M, Knowles P, Phillips S
Science
. 1999 Nov;
286(5445):1724-8.
PMID: 10576737
X-ray crystal structures of three species related to the oxidative half of the reaction of the copper-containing quinoprotein amine oxidase from Escherichia coli have been determined. Crystals were freeze-trapped either...
10.
Murray J, Saysell C, Wilmot C, Tambyrajah W, Jaeger J, Knowles P, et al.
Biochemistry
. 1999 Jul;
38(26):8217-27.
PMID: 10387067
Amine oxidases utilize a proton abstraction mechanism following binding of the amine substrate to the C5 position of the cofactor, the quinone form of trihydroxyphenylalanine (TPQ). Previous work [Wilmot, C....