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C J Jeffery

Explore the profile of C J Jeffery including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 488
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Recent Articles
1.
Lee J, Chang K, Patel V, Jeffery C
Biochemistry . 2001 Jun; 40(26):7799-805. PMID: 11425306
Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis. Biochemical characterization of the enzyme has...
2.
Pasternak A, White A, Jeffery C, Medina N, Cahoon M, Ringe D, et al.
Protein Sci . 2001 Jun; 10(7):1331-42. PMID: 11420435
The contribution of induced fit to enzyme specificity has been much debated, although with little experimental data. Here we probe the effect of induced fit on enzyme specificity using the...
3.
Jeffery C, Hardre R, Salmon L
Biochemistry . 2001 May; 40(6):1560-6. PMID: 11327814
Phosphoglucose isomerase (PGI; E.C. 5.3.1.9) catalyzes the second step in glycolysis, the interconversion of D-glucose-6-phosphate and D-fructose-6-phosphate. We determined the X-ray crystal structure of rabbit PGI complexed with a competitive...
4.
Jeffery C, Gloss L, Petsko G, Ringe D
Protein Eng . 2000 Mar; 13(2):105-12. PMID: 10708649
In previous kinetic studies of Escherichia coli aspartate aminotransferase, it was determined that some substitutions of conserved cysteine 191, which is located outside of the active site, altered the kinetic...
5.
Jeffery C, Bahnson B, Chien W, Ringe D, Petsko G
Biochemistry . 2000 Feb; 39(5):955-64. PMID: 10653639
The multifunctional protein phosphoglucose isomerase, also known as neuroleukin, autocrine motility factor, and differentiation and maturation mediator, has different roles inside and outside the cell. In the cytoplasm, it catalyzes...
6.
Jeffery C, Koshland Jr D
Protein Eng . 1999 Nov; 12(10):863-72. PMID: 10556247
The Escherichia coli aspartate receptor is a dimer with two transmembrane sequences per monomer that connect a periplasmic ligand binding domain to a cytoplasmic signaling domain. The method of 'hydrophobic-biased'...
7.
Jeffery C
Trends Biochem Sci . 1999 Mar; 24(1):8-11. PMID: 10087914
The idea of one gene--one protein--one function has become too simple because increasing numbers of proteins are found to have two or more different functions. The multiple functions of such...
8.
Jeffery C, Barry T, Doonan S, Petsko G, Ringe D
Acta Crystallogr D Biol Crystallogr . 1998 Oct; 54(Pt 4):659-61. PMID: 9761867
Diffraction-quality crystals of S. cerevisiae cytoplasmic aspartate aminotransferase have been obtained by the hanging-drop vapor-diffusion method in the presence of pyridoxal phosphate and maleic acid, sodium acetate, ammonium acetate and...
9.
Jeffery C, Barry T, Doonan S, Petsko G, Ringe D
Protein Sci . 1998 Jul; 7(6):1380-7. PMID: 9655342
The crystal structure of Saccharomyces cerevisiae cytoplasmic aspartate aminotransferase (EC 2.6.1.1) has been determined to 2.05 A resolution in the presence of the cofactor pyridoxal-5'-phosphate and the competitive inhibitor maleate....
10.
Jeffery C, Koshland Jr D
Biochemistry . 1994 Mar; 33(12):3457-63. PMID: 8142342
Many transmembrane receptors, such as the insulin, EGF, and bacterial chemotaxis receptors, have only one or a few transmembrane domains connecting an extracellular ligand-binding domain to a cytoplasmic signaling domain....