C H Orchard
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Explore the profile of C H Orchard including associated specialties, affiliations and a list of published articles.
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82
Citations
1834
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Recent Articles
1.
Orchard C, Bryant S, James A
J Physiol
. 2013 May;
591(17):4141-7.
PMID: 23652596
The transverse (t-) tubules of mammalian ventricular myocytes are invaginations of the surface membrane. The function of many of the key proteins involved in excitation-contraction coupling is located predominantly at...
2.
Pasek M, Simurda J, Orchard C
Eur Biophys J
. 2012 Apr;
41(6):491-503.
PMID: 22466899
The t-tubules of mammalian ventricular myocytes are invaginations of the surface membrane that form a complex network within the cell, with restricted diffusion to the bulk extracellular space. The trans-sarcolemmal...
3.
Du C, El Harchi A, Zhang Y, Orchard C, Hancox J
J Cardiovasc Electrophysiol
. 2011 Apr;
22(10):1163-70.
PMID: 21489024
Introduction: Human ether-à-go-go related gene (hERG) is responsible for channels that mediate the rapid delayed rectifier K(+) channel current (I(Kr) ), which participates in repolarization of the ventricles and is...
4.
Du C, El Harchi A, McPate M, Orchard C, Hancox J
Biochem Biophys Res Commun
. 2011 Jan;
405(2):222-7.
PMID: 21219869
Extracellular acidosis occurs in the heart during myocardial ischemia and can lead to dangerous arrhythmias. Potassium channels encoded by hERG (human ether-à-go-go-related gene) mediate the cardiac rapid delayed rectifier K+...
5.
Ridley J, Cheng H, Harrison O, Jones S, Smith G, Hancox J, et al.
Cell Calcium
. 2008 Jun;
44(6):580-91.
PMID: 18550162
Spontaneous Ca(2+) release from the sarcoplasmic reticulum (SR) appears to play an important role in cardiac sinoatrial node pacemaking. However, comparatively little is known about the role of intracellular Ca(2+)...
6.
Pasek M, Brette F, Nelson A, Pearce C, Qaiser A, Christe G, et al.
Prog Biophys Mol Biol
. 2007 Sep;
96(1-3):244-57.
PMID: 17881039
The transverse (t-) tubules of cardiac ventricular myocytes are invaginations of the surface membrane that form a complex network within the cell. Many of the key proteins involved in excitation-contraction...
7.
Pasek M, Simurda J, Christe G, Orchard C
Prog Biophys Mol Biol
. 2007 Sep;
96(1-3):226-43.
PMID: 17868782
The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region...
8.
Brette F, Salle L, Orchard C
Biophys J
. 2005 Oct;
90(1):381-9.
PMID: 16214862
The action potential of cardiac ventricular myocytes is characterized by its long duration, mainly due to Ca flux through L-type Ca channels. Ca entry also serves to trigger the release...
9.
Leach R, Desai J, Orchard C
Cell Calcium
. 2005 Sep;
38(5):515-26.
PMID: 16137761
The cytoskeleton plays an important role in many aspects of cardiac cell function, including protein trafficking. However, the role of the cytoskeleton in determining Ca channel location in cardiac myocytes...
10.
Brette F, Rodriguez P, Komukai K, Colyer J, Orchard C
J Mol Cell Cardiol
. 2004 Feb;
36(2):265-75.
PMID: 14871554
beta-adrenergic stimulation helps to synchronize Ca release in myocytes from failing hearts. Transverse (t-) tubules, which synchronize Ca release in normal cells and contain many of the elements of the...