C Garrison Fathman
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Explore the profile of C Garrison Fathman including associated specialties, affiliations and a list of published articles.
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75
Citations
3590
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Recent Articles
1.
Fathman C, Yip L, Gomez-Martin D, Yu M, Seroogy C, Hurt C, et al.
Front Immunol
. 2022 Dec;
13:1046631.
PMID: 36569931
Regulatory T cells (T) normally maintain self-tolerance. T recognize "self" such that when they are not working properly, such as in autoimmunity, the immune system can attack and destroy one's...
2.
Yip L, Alkhataybeh R, Taylor C, Fuhlbrigge R, Fathman C
Diabetes
. 2022 May;
71(7):1490-1507.
PMID: 35499603
Multiple pathways contribute to the pathophysiological development of type 1 diabetes (T1D); however, the exact mechanisms involved are unclear. We performed differential gene expression analysis in pancreatic islets of NOD...
3.
Yip L, Fuhlbrigge R, Alkhataybeh R, Fathman C
Front Endocrinol (Lausanne)
. 2021 Jan;
11:609271.
PMID: 33424774
Type 1 Diabetes (T1D) occurs as a result of the autoimmune destruction of pancreatic β-cells by self-reactive T cells. The etiology of this disease is complex and difficult to study...
4.
Rothbard J, Rothbard J, Soares L, Fathman C, Steinman L
Proc Natl Acad Sci U S A
. 2018 Jun;
115(27):7081-7086.
PMID: 29915045
Although certain dogma portrays amyloid fibrils as drivers of neurodegenerative disease and neuroinflammation, we have found, paradoxically, that amyloid fibrils and small heat shock proteins (sHsps) are therapeutic in experimental...
5.
Yip L, Fuhlbrigge R, Atkinson M, Fathman C
BMC Genomics
. 2017 Aug;
18(1):636.
PMID: 28821222
Background: The natural history of type 1 diabetes (T1D) is challenging to investigate, especially as pre-diabetic individuals are difficult to identify. Numerous T1D consortia have been established to collect whole...
6.
Edward J, Sanyal M, Le W, Soudry E, Ramakrishnan V, Bravo D, et al.
Clin Immunol
. 2017 Mar;
179:66-76.
PMID: 28279811
Severe forms of chronic rhinosinusitis (CRS), a common upper airway inflammatory disorder, are associated with nasal polyps (NPs). NP disease is ameliorated by glucocorticoid (GC) treatment, whose cellular effects are...
7.
Kodama K, Zhao Z, Toda K, Yip L, Fuhlbrigge R, Miao D, et al.
Diabetes
. 2016 Mar;
65(5):1341-9.
PMID: 26983959
Type 1 diabetes (T1D) is caused by autoreactive T cells that recognize pancreatic islet antigens and destroy insulin-producing β-cells. This attack results from a breakdown in tolerance for self-antigens, which...
8.
Creusot R, Battaglia M, Roncarolo M, Fathman C
Stem Cells
. 2016 Feb;
34(4):809-19.
PMID: 26840009
The evolution of Type 1 diabetes (T1D) therapy has been marked by consecutive shifts, from insulin replacement to immunosuppressive drugs and targeted biologics (following the understanding that T1D is an...
9.
Kurnellas M, Ghosn E, Schartner J, Baker J, Rothbard J, Negrin R, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
112(49):15016-23.
PMID: 26621719
Amyloid fibrils composed of peptides as short as six amino acids are therapeutic in experimental autoimmune encephalomyelitis (EAE), reducing paralysis and inflammation, while inducing several pathways of immune suppression. Intraperitoneal...
10.
Whiting C, Siebert J, Newman A, Du H, Alizadeh A, Goronzy J, et al.
PLoS One
. 2015 Jul;
10(7):e0133627.
PMID: 26197454
While many age-associated immune changes have been reported, a comprehensive set of metrics of immune aging is lacking. Here we report data from 243 healthy adults aged 40-97, for whom...