C E Patek
Overview
Explore the profile of C E Patek including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
145
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Recent Articles
1.
Luo F, Brooks D, Ye H, Hamoudi R, Poulogiannis G, Patek C, et al.
Oncogene
. 2007 Feb;
26(30):4415-27.
PMID: 17297472
K-ras mutation occurs in 40-50% of human colorectal adenomas and carcinomas, but its contribution to intestinal tumorigenesis in vivo is unclear. We developed K-ras(V12) transgenic mice that were crossed with...
2.
Plowman S, Berry R, Bader S, Luo F, Arends M, Harrison D, et al.
J Exp Clin Cancer Res
. 2006 Aug;
25(2):259-67.
PMID: 16918139
Ras activating mutations result in constitutive activation of Ras signalling pathways and occur in 30% of human malignancies. K-ras encodes two splice variants, K-ras 4A and 4B, and K-ras activating...
3.
Patek C, Saunders P, Miles C, Berry R, Hastie N, Sharpe R, et al.
Transgenic Res
. 2005 Oct;
14(5):691-702.
PMID: 16245160
Gonadal effects of the Denys-Drash syndrome (DDS) mutation Wt1(tmT396 )were examined in chimaeric and heterozygous mice. Since the only heterozygote was 41,XXY, Sertoli cell function was assessed by comparison with...
4.
Wagner K, Patek C, Cunningham A, Taylor A, Hooper M, Ansell J
Blood Cells Mol Dis
. 2002 Oct;
28(3):428-35.
PMID: 12367587
The effect of mutations that truncate the WT1 protein on in vitro hematopoietic differentiation from embryonal stem cells has been examined by CFU-A assay, o-dianisidine staining for heme, and RT-PCR...
5.
Wagner K, Patek C, Miles C, Christie S, Brookes A, Hooper M
Biochem Biophys Res Commun
. 2001 Sep;
287(4):977-82.
PMID: 11573961
Mutations in the WT1 gene are found in a subset of Wilms' tumours and in certain other disorders such as Denys-Drash syndrome. The WT1 gene product is a zinc finger...
6.
Brooks D, James R, Patek C, Williamson J, Arends M
Oncogene
. 2001 May;
20(17):2144-52.
PMID: 11360198
The roles of K-ras in neoplasia are not entirely understood, although there is evidence that K-ras affects susceptibility to apoptosis, modulating survival of DNA damaged cells which would otherwise be...
7.
Patek C, Little M, Fleming S, Miles C, Charlieu J, Clarke A, et al.
Proc Natl Acad Sci U S A
. 1999 Mar;
96(6):2931-6.
PMID: 10077614
The Wilms tumor-suppressor gene, WT1, plays a key role in urogenital development, and WT1 dysfunction is implicated in both neoplastic (Wilms tumor, mesothelioma, leukemias, and breast cancer) and nonneoplastic (glomerulosclerosis)...
8.
Patek C, Jeanny J, Clayton R
Exp Eye Res
. 1993 Nov;
57(5):527-37.
PMID: 8282039
We have shown that cultured day-old chick lens epithelial cells undergo changes in crystallin expression during lens fibre (lentoid body) differentiation and ageing in serial subculture which are similar to...
9.
Patek C, Kerr J, Gosden R, Jones K, Hardy K, Handyside A, et al.
Development
. 1991 Sep;
113(1):311-25.
PMID: 1765003
Adult intraspecific mouse chimaeras, derived by introducing male embryonal stem cells into unsexed host blastocysts, were examined to determine whether gonadal sex was correlated with the sex chromosome composition of...
10.
Ansell J, Samuel K, WHITTINGHAM D, Patek C, Hardy K, Handyside A, et al.
Development
. 1991 Jun;
112(2):489-98.
PMID: 1794318
We have looked for effects of deficiency in hypoxanthine phosphoribosyl transferase (HPRT) in the mouse comparable to non-behavioural consequences of HPRT-deficiency in humans. HPRT-deficient humans show abnormalities in haematopoiesis and,...