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C Denef

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Articles 136
Citations 835
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Recent Articles
1.
Pals K, Roudbaraki M, Denef C
J Neuroendocrinol . 2008 Mar; 20(5):535-48. PMID: 18363807
Fourteen-day-old rat pituitary tissue represents an attractive model for studying cell population dynamics, particularly of gonadotrophs. Prolonged three-dimensional culture in serum- and hormone-free medium causes a striking decline in somatotroph...
2.
Denef C
J Neuroendocrinol . 2007 Dec; 20(1):1-70. PMID: 18081553
Living organisms represent, in essence, dynamic interactions of high complexity between membrane-separated compartments that cannot exist on their own, but reach behaviour in co-ordination. In multicellular organisms, there must be...
3.
Papageorgiou A, Denef C
Endocrinology . 2007 Jun; 148(9):4509-22. PMID: 17584957
5-Hydroxytryptamine (5-HT) promotes the release of GH by a hypothalamic site of action. The present study explores a putative pituitary action in a perifused rat anterior pituitary aggregate cell culture...
4.
Van As P, Janssens K, Pals K, De Groef B, Onagbesan O, Bruggeman V, et al.
Acta Vet Hung . 2007 Feb; 54(4):455-71. PMID: 17278718
Pit-1 is a pituitary-specific POU-domain DNA binding factor, which binds to and trans-activates promoters of growth hormone- (GH), prolactin- (PRL) and thyroid stimulating hormone-beta- (TSHbeta) encoding genes. Thyrotropin-releasing hormone (TRH)...
5.
Papageorgiou A, Denef C
Endocrinology . 2006 Nov; 148(3):1384-95. PMID: 17122082
Serotonin [5-hydroxytryptamine (5-HT)] is known to control prolactin (PRL) release at a hypothalamic level, but a pituitary site of action remains poorly studied. The present study explores the acute effect...
6.
Pals K, Boussemaere M, Swinnen E, Vankelecom H, Denef C
Endocrinology . 2006 Jul; 147(10):4738-52. PMID: 16840545
Promiscuous hormone mRNA expression in the pituitary remains poorly understood. We examined by means of RT-PCR and immunostaining whether glycoprotein hormone alpha-subunit (alphaGSU) could be coexpressed with proopiomelanocortin (POMC) in...
7.
Pals K, Vankelecom H, Denef C
J Neuroendocrinol . 2006 Feb; 18(3):203-16. PMID: 16454804
In the present study, we used a three-dimensional pituitary cell culture system from early postnatal rats to examine the in vitro developmental potential of triiodothyronine (T3) and thyrotrophin-releasing hormone (TRH)....
8.
Swinnen E, Boussemaere M, Denef C
J Neuroendocrinol . 2005 Jun; 17(6):379-86. PMID: 15929743
Although the G-protein coupled receptor GPR10 is highly expressed in the anterior pituitary, the action of its ligand prolactin-releasing peptide-31 (PrRP) in this tissue is controversial. The present study examined...
9.
Denef C, Pals K, Hauspie A, Vankelecom H, Seuntjens E
Ann N Y Acad Sci . 2005 May; 1040:84-8. PMID: 15891010
As studied by single cell RT-PCR of pituitary hormones, we demonstrated that the pituitaries of rats and mice contain a subpopulation of cells that express two or more hormone phenotypes...
10.
Langouche L, Hersmus N, Papageorgiou A, Vankelecom H, Denef C
J Neuroendocrinol . 2004 Jul; 16(8):695-703. PMID: 15271062
Treatment for 40 h of reaggregate pituitary cell cultures from 14-day-old female rats with nanomolar concentrations of gamma3-melanocyte-stimulating hormone (MSH) increased prolactin mRNA but not growth hormone (GH) mRNA expression...