C den Besten
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Explore the profile of C den Besten including associated specialties, affiliations and a list of published articles.
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15
Citations
66
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Recent Articles
1.
den Besten C, Korosi S, Beamand J, Walters D, Lake B
Toxicol In Vitro
. 2010 Aug;
4(4-5):518-21.
PMID: 20702224
Rat hepatocyte suspensions have been used as a model system for some studies on the mechanism of coumarin-induced hepatotoxicity. Hepatocytes were isolated from male Sprague-Dawley rats and subjected to Percoll...
2.
Rietjens I, den Besten C, Hanzlik R, van Bladeren P
Chem Res Toxicol
. 1997 Jun;
10(6):629-35.
PMID: 9208168
No abstract available.
3.
Rietjens I, Steensma A, den Besten C, van Tintelen G, Haas J, van Ommen B, et al.
Eur J Pharmacol
. 1995 Dec;
293(4):293-9.
PMID: 8748681
The porphyrinogenic action of hexafluorobenzene was investigated and compared to that of hexachlorobenzene. Metabolite patterns in the urine of exposed rats were determined to quantify the extent of metabolism through...
4.
Schielen P, den Besten C, Vos J, van Bladeren P, Seinen W, Bloksma N
Toxicol Appl Pharmacol
. 1995 Mar;
131(1):37-43.
PMID: 7878676
The role of metabolism and porphyria in the immunomodulating effects of hexachlorobenzene (HCB) was investigated. To this end, female Wistar rats received a diet with two different doses of HCB...
5.
den Besten C, Brouwer A, Rietjens I, van Bladeren P
Hum Exp Toxicol
. 1994 Dec;
13(12):866-75.
PMID: 7718307
1. Multiple potentially harmful metabolites can be distinguished in the metabolic activation of halogenated benzenes: epoxides, phenols, benzoquinones and benzoquinone-derived glutathione conjugates. 2. The role of these (re-) active metabolites...
6.
Comparison of the urinary metabolite profiles of hexachlorobenzene and pentachlorobenzene in the rat
den Besten C, Bennik M, van Iersel M, Peters M, Teunis C, van Bladeren P
Chem Biol Interact
. 1994 Feb;
90(2):121-37.
PMID: 8156603
The urinary metabolite profile of hexachlorobenzene (HCB) and pentachlorobenzene (PCBz) in the rat is compared after dietary exposure for 13 weeks. Both HCB and PCBz are oxidized to pentachlorophenol (PCP)...
7.
den Besten C, van Bladeren P, Duizer E, Vervoort J, Rietjens I
Chem Res Toxicol
. 1993 Sep;
6(5):674-80.
PMID: 8292746
In the present study the oxidative dehalogenation of a para-halogenated phenol was studied using pentafluorophenol and its non-para-halogenated analogue 2,3,5,6-tetrafluorophenol as model compounds. 19F NMR was used to characterize the...
8.
den Besten C, Bennik M, Bruggeman I, Schielen P, Kuper F, Brouwer A, et al.
Toxicol Appl Pharmacol
. 1993 Apr;
119(2):181-94.
PMID: 8480328
Hexachlorobenzene (HCB) induces a broad spectrum of effects including disturbances in the heme synthesis (porphyria) and in thyroid hormone homeostasis. For most of its effects, biotransformation of the parent compound...
9.
den Besten C, Ellenbroek M, van der Ree M, Rietjens I, van Bladeren P
Chem Biol Interact
. 1992 Nov;
84(3):259-75.
PMID: 1423744
The microsomal oxidation of 1,2-[14C]- and 1,4-[14C]dichlorobenzene (DICB) was investigated with special attention for possible differences in biotransformation that might contribute to the isomer-specific hepatotoxicity. Major metabolites of both isomers...
10.
den Besten C, Vet J, Besselink H, Kiel G, van Berkel B, Beems R, et al.
Toxicol Appl Pharmacol
. 1991 Oct;
111(1):69-81.
PMID: 1949037
The acute toxicity of a number of chlorinated benzenes, ranging from monosubstituted to pentasubstituted benzenes, was studied in rats. Toxic effects on the liver, the kidneys, and the thyroid were...