C D Rosin
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Explore the profile of C D Rosin including associated specialties, affiliations and a list of published articles.
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4
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10
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Recent Articles
1.
Coevolution and subsite decomposition for the design of resistance-evading HIV-1 protease inhibitors
Rosin C, Belew R, Walker W, Morris G, Olson A, Goodsell D
J Mol Biol
. 1999 Mar;
287(1):77-92.
PMID: 10074408
Drug resistance sharply limits the effectiveness of human immunodeficiency virus (HIV) protease inhibitors in acquired immunodeficiency syndrome therapy. In previous work, we presented methods for design of resistance-evading inhibitors using...
2.
Rosin C, Belew R, Morris G, Olson A, Goodsell D
Proc Natl Acad Sci U S A
. 1999 Feb;
96(4):1369-74.
PMID: 9990030
We have developed a coevolutionary method for the computational design of HIV-1 protease inhibitors selected for their ability to retain efficacy in the face of protease mutation. For HIV-1 protease,...
3.
Rosin C, Belew R, Morris G, Olson A, Goodsell D
Artif Life
. 1998 Nov;
4(1):41-59.
PMID: 9798274
An understanding of antiviral drug resistance is important in the design of effective drugs. Comprehensive features of the interaction between drug designs and resistance mutations are difficult to study experimentally...
4.
Rosin C, Belew R
Evol Comput
. 1997 Apr;
5(1):1-29.
PMID: 10021751
We consider "competitive coevolution," in which fitness is based on direct competition among individuals selected from two independently evolving populations of "hosts" and "parasites." Competitive coevolution can lead to an...