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C Barroga

Explore the profile of C Barroga including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 2
Citations 161
Followers 0
Related Specialties
Orthopedics
Rheumatology
Top 10 Co-Authors
Y Yazici
M Ibanez
L Do
S Cho
B Tam
J Cahiwat
V Deshmukh
T Seo
K Chiu
S Kc
Published In
Osteoarthritis Cartilage
Affiliations
Soon will be listed here.
Recent Articles
1.
Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment
Deshmukh V, OGreen A, Bossard C, Seo T, Lamangan L, Ibanez M, et al.
Osteoarthritis Cartilage . 2019 May; 27(9):1347-1360. PMID: 31132406
Objectives: Wnt pathway upregulation contributes to knee osteoarthritis (OA) through osteoblast differentiation, increased catabolic enzymes, and inflammation. The small-molecule Wnt pathway inhibitor, lorecivivint (SM04690), which previously demonstrated chondrogenesis and cartilage...
2.
A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee
Deshmukh V, Hu H, Barroga C, Bossard C, Kc S, Dellamary L, et al.
Osteoarthritis Cartilage . 2017 Sep; 26(1):18-27. PMID: 28888902
Objectives: Osteoarthritis (OA) is a degenerative disease characterized by loss of cartilage and increased subchondral bone within synovial joints. Wnt signaling affects the pathogenesis of OA as this pathway modulates...