C A Thornton
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Explore the profile of C A Thornton including associated specialties, affiliations and a list of published articles.
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62
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2362
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Recent Articles
1.
Bryant A, Menzies G, Scott L, Spencer-Harty S, Davies L, Smith R, et al.
Clin Exp Immunol
. 2017 Mar;
189(1):36-46.
PMID: 28295207
The role of viral infections in adverse pregnancy outcomes has gained interest in recent years. Innate immune pattern recognition receptors (PRRs) and their signalling pathways, that yield a cytokine output...
2.
Thornton C
Ir J Med Sci
. 2016 Aug;
148(1):207.
PMID: 27517422
A retrospective clinical analysis of the 66 intrapartum deaths which occurred among the 41, 613 births at the Rotunda Hospital during the 8-year period January 1970 to December 1977 was...
3.
Cronin J, Kanamarlapudi V, Thornton C, Sheldon I
Mucosal Immunol
. 2016 Jan;
9(5):1125-36.
PMID: 26813342
Interleukin 6 (IL-6), acting via the IL-6 receptor (IL6R) and signal transducer and activator of transcription-3 (STAT3), limits neutrophil recruitment once bacterial infections are resolved. Bovine endometritis is an exemplar...
4.
Jones N, Piasecka J, Bryant A, Jones R, Skibinski D, Francis N, et al.
Clin Exp Immunol
. 2015 Jun;
182(1):69-80.
PMID: 26032049
Leucocytes respond rapidly to pathogenic and other insults, with responses ranging from cytokine production to migration and phagocytosis. These are bioenergetically expensive, and increased glycolytic flux provides adenosine triphosphate (ATP)...
5.
Catling S, Thornton C, Russell I
Anaesthesia
. 2015 Apr;
70(9):1066-72.
PMID: 25920728
It has been suggested that giving cell-salvaged blood through a leucocyte depletion filter can cause hypotension due to bradykinin released when factor XII and platelets are activated by the negatively...
6.
Campbell D, Boyle R, Thornton C, Prescott S
Clin Exp Allergy
. 2015 Mar;
45(5):844-858.
PMID: 25772780
Allergic disease can be viewed as an early manifestation of immune dysregulation. Environmental exposures including maternal inflammation, diet, nutrient balance, microbial colonization and toxin exposures can directly and indirectly influence...
7.
Gordon J, Prothero J, Thornton C, Pickard K, di Sabatino A, Goggin P, et al.
J Crohns Colitis
. 2010 Dec;
3(3):175-82.
PMID: 21172267
Background: Thalidomide, one of whose activities is to inhibit Tumour Necrosis Factor (TNF)-α production, has been reported to be an effective treatment for refractory inflammatory bowel disease (IBD). TNF-α driven...
8.
Logigian E, Martens W, Moxley 4th R, McDermott M, Dilek N, Wiegner A, et al.
Neurology
. 2010 May;
74(18):1441-8.
PMID: 20439846
Objective: To determine if mexiletine is safe and effective in reducing myotonia in myotonic dystrophy type 1 (DM1). Background: Myotonia is an early, prominent symptom in DM1 and contributes to...
9.
Musser W, Barbano R, Thornton C, Moxley 3rd R, Herrmann D, Logigian E
J Clin Neuromuscul Dis
. 2008 Dec;
3(1):16-9.
PMID: 19078648
We present two patients with distal myasthenia gravis poorly responsive to immunomodulatory therapy. In addition to a typical decrement on slow repetitive nerve stimulation, both had borderline to low compound...
10.
Sorenson E, Windbank A, Mandrekar J, Bamlet W, Appel S, Armon C, et al.
Neurology
. 2008 Nov;
71(22):1770-5.
PMID: 19029516
Background: Previous human clinical trials of insulin-like growth factor type I (IGF-1) in amyotrophic lateral sclerosis (ALS) have been inconsistent. This phase III, randomized, double-blind, placebo-controlled study was undertaken to...