C A Bate
Overview
Explore the profile of C A Bate including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
440
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Recent Articles
1.
Scragg I, Hensmann M, Bate C, Kwiatkowski D
Eur J Immunol
. 1999 Aug;
29(8):2636-44.
PMID: 10458778
We have investigated the widely held view that malaria parasites induce pro-inflammatory cytokines primarily through an endotoxin-like stimulatory effect on macrophages. We report that the pattern of cytokine production by...
2.
Kwiatkowski D, Bate C, Scragg I, Beattie P, Udalova I, Knight J
Ann Trop Med Parasitol
. 1997 Jul;
91(5):533-42.
PMID: 9329990
It is estimated that over 200 million people each year suffer debilitating attacks of malarial fever, and roughly 2 million of these episodes are fatal. The fever is caused by...
3.
Rockett K, Kwiatkowski D, Bate C, Awburn M, Rockett E, Clark I
J Infect
. 1996 May;
32(3):187-96.
PMID: 8793707
Malarial illness and pathology is generally accepted to be caused by material released when the infected red cells burst at schizogony. The released material has been partially purified and shown...
4.
Jakobsen P, Bate C, Taverne J, Playfair J
Parasite Immunol
. 1995 May;
17(5):223-31.
PMID: 7675508
In this review the old concept of severe malaria as a toxic disease is re-examined in the light of recent discoveries in the field of cytokines. Animal studies suggest that...
5.
Bate C, Kwiatkowski D
Infect Immun
. 1994 Dec;
62(12):5261-6.
PMID: 7960103
The clinical symptoms of human malaria are mediated, at least in part, by the release of tumor necrosis factor alpha (TNF) by monocytes and macrophages. We have found that lysates...
6.
Bate C, Kwiatkowski D
Immunology
. 1994 Oct;
83(2):256-61.
PMID: 7835944
We sought to characterize factors released by sonicated human erythrocytes that stimulate peripheral blood mononuclear cells (PBMC) to release tumour necrosis factor-alpha (TNF). This response is not inhibited by polymyxin...
7.
Bate C, Kwiatkowski D
Infect Immun
. 1994 Aug;
62(8):3086-91.
PMID: 8039876
Cytokines such as tumor necrosis factor alpha (TNF) appear to play an important role in the pathogenesis of malaria. We have previously shown that TNF is produced in response to...
8.
Bate C, Taverne J, Kwiatkowski D, Playfair J
Immunology
. 1993 May;
79(1):138-45.
PMID: 8509134
Phospholipid-containing antigens of malaria parasites stimulate macrophages to secrete tumour necrosis factor (TNF), induce hypoglycaemia and are toxic to mice. This TNF induction is inhibited by antisera made against the...
9.
Jakobsen P, Moon R, Ridley R, Bate C, Taverne J, Hansen M, et al.
Parasite Immunol
. 1993 Apr;
15(4):229-37.
PMID: 8506119
P. falciparum merozoite antigens, merozoite surface protein-1 (MSP-1) and rhoptry associated protein-1 (RAP-1), were shown to be liberated into the supernatant of in vitro parasite cultures and to be included...
10.
Taylor K, Bate C, Carr R, Butcher G, Taverne J, Playfair J
Clin Exp Immunol
. 1992 Oct;
90(1):1-5.
PMID: 1395089
Hypoglycaemia is associated with severe malaria and is an important prognostic indicator. Molecules liberated during overnight incubation of erythrocytes infected with Plasmodium yoelii induce marked hypoglycaemia in normal mice, with...