Bryan J McCranor
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Explore the profile of Bryan J McCranor including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
117
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Recent Articles
1.
Tuet W, Pierce S, Conroy M, Vignola J, Tressler J, diTargiani R, et al.
Pharmacol Res Perspect
. 2022 Sep;
10(5):e01000.
PMID: 36045607
The opioid crisis is a pressing public health issue, exacerbated by the emergence of more potent synthetic opioids, particularly fentanyl and its analogs. While competitive antagonists exist, their efficacy against...
2.
Tuet W, Pierce S, Racine M, Stone S, Pueblo E, Dukes A, et al.
Toxicol Appl Pharmacol
. 2021 Jul;
427:115652.
PMID: 34298059
Exposure to phosphine (PH) presents with a host of diverse, non-specific symptoms that span multiple organ systems and is characterized by a high mortality rate. While a comprehensive mechanism for...
3.
McCranor B, Jennings L, Tressler J, Tuet W, DeLey Cox V, Racine M, et al.
Toxicol Rep
. 2020 Sep;
7:1112-1120.
PMID: 32864344
Carfentanil is a powerful synthetic opioid that is approximately 100 times more potent than fentanyl and 10,000 times more potent than morphine. Carfentanil was originally intended to be used as...
4.
DeLey Cox V, Hartog M, Pueblo E, Racine M, Jennings L, Tressler J, et al.
Ann N Y Acad Sci
. 2020 Apr;
1479(1):196-209.
PMID: 32285953
Fluoroacetate (FA) is a tasteless, odorless, water-soluble metabolic poison with severe toxicological effects. Characterized in the mid-1900s, it has been used as a rodenticide but is comparably lethal to all...
5.
Tuet W, Racine M, Jennings L, Pierce S, Tressler J, McCranor B, et al.
Ann N Y Acad Sci
. 2020 Apr;
1479(1):168-179.
PMID: 32242940
Exposure to phosphine (PH ), a common grain fumigant, is characterized by diverse nonspecific symptoms and a high mortality rate. Although PH poisoning is thought to target oxidative respiration, the...
6.
McCranor B, Young T, Tressler J, Jennings L, Irwin J, Alli N, et al.
Cogent Biol
. 2019 Oct;
5(1).
PMID: 31595219
Sodium fluoroacetate (1080) is a highly toxic metabolic poison that has the potential because of its lack of defined color, odor, and taste and its high water solubility to be...
7.
Tuet W, Pierce S, Racine M, Tressler J, McCranor B, Sciuto A, et al.
Toxicol Lett
. 2019 Sep;
316:127-135.
PMID: 31539569
Carfentanil (CRF) is an extremely potent opioid capable of inducing fatal respiratory depression. Naloxone (NX) and naltrexone (NTX) are opioid antagonists for which the efficacy against CRF remains largely unexplored....
8.
McCranor B, Hofstetter C, Olert M, Moorad-Doctor D, Cerasoli D, Garcia G
Chem Biol Interact
. 2016 May;
259(Pt B):205-210.
PMID: 27163849
To develop a prophylactic for organophosphorus (OP) poisoning utilizing catalytic bioscavengers, the circulatory stability of the enzymes needs to be increased. One strategy for increasing the bioavailability of OP bioscavengers...
9.
McCranor B, Szmacinski H, Zeng H, Stoddard A, Hurst T, Fierke C, et al.
Metallomics
. 2014 Mar;
6(5):1034-42.
PMID: 24671220
Copper is a required trace element that plays key roles in a number of human enzymes, such that copper deficiency or genetic defects in copper transport lead to serious or...
10.
Langdon J, Yates S, Femnou L, McCranor B, Cheadle C, Xue Q, et al.
Am J Hematol
. 2014 Jan;
89(5):470-9.
PMID: 24415655
Increased hepcidin antimicrobial peptide correlates with hypoferremia and anemia in various disease states, but its requirement for anemia of inflammation has not been adequately demonstrated. Anemia of inflammation is usually...