Bruce N Ames
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Explore the profile of Bruce N Ames including associated specialties, affiliations and a list of published articles.
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86
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3830
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Recent Articles
11.
Suh J, Kanathezhath B, Shenvi S, Guo H, Zhou A, Tiwana A, et al.
PLoS One
. 2014 Feb;
9(2):e88868.
PMID: 24558439
Graft-versus-host disease (GVHD) is a common complication of allogeneic bone marrow transplantation (BMT). Upregulation of inflammatory cytokines precedes the clinical presentation of GVHD and predicts its severity. In this report,...
12.
Patrick R, Ames B
FASEB J
. 2014 Feb;
28(6):2398-413.
PMID: 24558199
Serotonin and vitamin D have been proposed to play a role in autism; however, no causal mechanism has been established. Here, we present evidence that vitamin D hormone (calcitriol) activates...
13.
Harrison D, Strong R, Allison D, Ames B, Astle C, Atamna H, et al.
Aging Cell
. 2013 Nov;
13(2):273-82.
PMID: 24245565
Four agents--acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB)--were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by...
14.
Mietus-Snyder M, Shigenaga M, Suh J, Shenvi S, Lal A, McHugh T, et al.
FASEB J
. 2012 May;
26(8):3515-27.
PMID: 22549511
Dietary intake modulates disease risk, but little is known how components within food mixtures affect pathophysiology. A low-calorie, high-fiber, fruit-based nutrient-dense bar of defined composition (e.g., vitamins and minerals, fruit...
15.
Wang Y, Moreland M, Wagner J, Ames B, Illek B, Peden D, et al.
J Nutr Biochem
. 2011 Jul;
23(6):602-8.
PMID: 21764283
Eotaxin-3 (CCL-26), a potent chemokine for eosinophil recruitment and contributing significantly to the pathogenesis of asthma, is secreted by lung epithelial cells in response to T helper 2 cytokines including...
16.
McCann J, Ames B
FASEB J
. 2011 Mar;
25(6):1793-814.
PMID: 21402715
The triage theory proposes that modest deficiency of any vitamin or mineral (V/M) could increase age-related diseases. V/M-dependent proteins required for short-term survival and/or reproduction (i.e., "essential") are predicted to...
17.
Lal A, Ames B
Mutagenesis
. 2010 Dec;
26(1):57-62.
PMID: 21164183
Epidemiological studies reveal strong association between micronutrient deficiencies and development of cancer. Since chromosome breaks and abnormal chromosome segregation, identified as micronuclei (MN), are central to malignant transformation, the influence...
18.
Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake
Ames B
J Nucleic Acids
. 2010 Oct;
2010.
PMID: 20936173
I review three of our research efforts which suggest that optimizing micronutrient intake will in turn optimize metabolism, resulting in decreased DNA damage and less cancer as well as other...
19.
Ames B
Mech Ageing Dev
. 2010 Apr;
131(7-8):473-9.
PMID: 20420847
Three of our research efforts are reviewed, which suggest that optimizing metabolism will delay aging and the diseases of aging in humans. (1) Research on delay of the mitochondrial decay...
20.
McCann J, Ames B
Am J Clin Nutr
. 2009 Aug;
90(4):889-907.
PMID: 19692494
The triage theory posits that some functions of micronutrients (the approximately 40 essential vitamins, minerals, fatty acids, and amino acids) are restricted during shortage and that functions required for short-term...