Bruce A Witthuhn
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Explore the profile of Bruce A Witthuhn including associated specialties, affiliations and a list of published articles.
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20
Citations
348
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Recent Articles
1.
Sekine Y, Kikkawa K, Witthuhn B, Kashiwakura J, Muromoto R, Kitai Y, et al.
Int Immunol
. 2022 Feb;
34(6):303-312.
PMID: 35192696
Jak3, a member of the Janus kinase family, is essential for the cytokine receptor common gamma chain (γc)-mediated signaling. During activation of Jak3, tyrosine residues are phosphorylated and potentially regulate...
2.
Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
Najt C, Khan S, Heden T, Witthuhn B, Perez M, Heier J, et al.
Mol Cell
. 2020 Jan;
77(4):810-824.e8.
PMID: 31901447
Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via...
3.
Kosyakovsky J, Witthuhn B, Svitak A, Frey 2nd W, Hanson L, Fine J
ACS Chem Neurosci
. 2019 Oct;
10(11):4571-4578.
PMID: 31573798
Deferoxamine, a metal chelator, has been shown to be neuroprotective in animal models of ischemic stroke, traumatic brain injury and both subarachnoid and intracerebral hemorrhage. Intranasal deferoxamine (IN DFO) has...
4.
Lindsay A, Chamberlain C, Witthuhn B, Lowe D, Ervasti J
Hum Mol Genet
. 2018 Nov;
28(6):942-951.
PMID: 30476171
Duchenne muscular dystrophy is a deadly muscle-wasting disorder caused by loss of dystrophin protein. Studies suggest that metabolic alterations are important to disease pathogenesis. Because muscle accounts for ~40% of...
5.
Ghosal R, Eichmiller J, Witthuhn B, Sorensen P
Ecol Evol
. 2018 Sep;
8(13):6714-6727.
PMID: 30220992
Measurement of environmental DNA (eDNA) is becoming a common technique to survey for rare and invasive fish due to its sensitivity and specificity. However, its utility is limited by an...
6.
Hodgson S, Griffin T, Reilly C, Harvey S, Witthuhn B, Sandri B, et al.
BMJ Open Respir Res
. 2017 Apr;
4(1):e000180.
PMID: 28409005
Introduction: Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity in persons living with HIV (PLWH) and HIV appears to uniquely cause COPD, independent of smoking. The mechanisms...
7.
Gulcev M, Reilly C, Griffin T, Broeckling C, Sandri B, Witthuhn B, et al.
Int J Chron Obstruct Pulmon Dis
. 2016 Oct;
11:2435-2446.
PMID: 27729784
Introduction: Exacerbations are a leading cause of morbidity in COPD. The objective of this study was to identify metabolomic biomarkers of acute exacerbations of COPD (AECOPD). Methods: We measured metabolites...
8.
Baldridge G, Markowski T, Witthuhn B, Higgins L, Baldridge A, Fallon A
In Vitro Cell Dev Biol Anim
. 2015 Oct;
52(1):77-88.
PMID: 26427709
Wolbachia pipientis (Rickettsiales), an obligate intracellular alphaproteobacterium in insects, manipulates host reproduction to maximize invasion of uninfected insect populations. Modification of host population structure has potential applications for control of...
9.
Baldridge G, Li Y, Witthuhn B, Higgins L, Markowski T, Baldridge A, et al.
Arch Microbiol
. 2015 Sep;
198(1):53-69.
PMID: 26400107
The obligate intracellular bacterium, Wolbachia pipientis (Rickettsiales), is a widespread, vertically transmitted endosymbiont of filarial nematodes and arthropods. In insects, Wolbachia modifies reproduction, and in mosquitoes, infection interferes with replication...
10.
Baldridge G, Baldridge A, Witthuhn B, Higgins L, Markowski T, Fallon A
Mol Microbiol
. 2014 Aug;
94(3):537-56.
PMID: 25155417
Wolbachia pipientis, a widespread vertically transmitted intracellular bacterium, provides a tool for insect control through manipulation of host-microbe interactions. We report proteomic characterization of wStr, a Wolbachia strain associated with...