Brit Nacke
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Explore the profile of Brit Nacke including associated specialties, affiliations and a list of published articles.
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8
Citations
76
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Recent Articles
1.
Friedemann M, Gutewort K, Thiem D, Nacke B, Jandeck C, Lange B, et al.
Sci Rep
. 2020 Jun;
10(1):9058.
PMID: 32493972
Acute lymphoblastic leukaemia (ALL) is the most common form of paediatric cancer and epigenetic aberrations are determinants of leukaemogenesis. The aim of this study was to investigate the methylation degree...
2.
Menschikowski M, Jandeck C, Friedemann M, Nacke B, Hantsche S, Tiebel O, et al.
Oncotarget
. 2018 Dec;
9(90):36137-36150.
PMID: 30546833
Background: The analysis of aberrant DNA methylations is used for the diagnosis of cancer as significant changes in the gene methylation pattern are often detected during early carcinogenesis. In this...
3.
Friedemann M, Nacke B, Hagelgans A, Jandeck C, Bechmann N, Ullrich M, et al.
Oncotarget
. 2018 Dec;
9(89):35983-35996.
PMID: 30542512
Physiological and pathophysiological functions of the phospholipase A2 receptor 1 (PLA2R1) are still not completely understood. To elucidate PLA2R1's function in prostate carcinoma, the receptor was ectopically overexpressed in LNCaP...
4.
Menschikowski M, Hagelgans A, Nacke B, Jandeck C, Mareninova O, Asatryan L, et al.
Tumour Biol
. 2015 Dec;
37(6):8097-105.
PMID: 26715269
Secreted phospholipases A2 (sPLA2) are suggested to play an important role in inflammation and tumorigenesis. Different mechanisms of epigenetic regulation are involved in the control of group IIA, III and...
5.
Menschikowski M, Hagelgans A, Nacke B, Jandeck C, Sukocheva O, Siegert G
BMC Cancer
. 2015 Dec;
15:971.
PMID: 26672991
Background: It has recently been proposed that the M-type phospholipase A2 receptor (PLA2R1) acts as a tumour suppressor in certain malignancies including mammary cancer. Considering that DNA methylation is an...
6.
Richter S, Klink B, Nacke B, de Cubas A, Mangelis A, Rapizzi E, et al.
J Clin Endocrinol Metab
. 2015 Dec;
101(2):359-63.
PMID: 26652933
Context: Mutational inactivation of the succinate dehydrogenase (SDH) complex is a well-described cause of tumor development in pheochromocytomas/paragangliomas (PPGLs) and gastrointestinal stromal tumors (GISTs). Epigenetic inactivation of the SDHC gene...
7.
Hagelgans A, Nacke B, Zamaraeva M, Siegert G, Menschikowski M
Anticancer Res
. 2014 Apr;
34(4):1723-9.
PMID: 24692702
Background: Silibinin, a naturally-occurring flavonoid produced by milk thistle, possesses antioxidant, anti-inflammatory and cancer-preventive activities. In the current study, we examined the effects of silibinin on the expression of secreted...
8.
Hagelgans A, Menschikowski M, Fuessel S, Nacke B, Arneth B, Wirth M, et al.
Exp Mol Pathol
. 2013 Apr;
94(3):458-65.
PMID: 23541763
Plasminogen activator inhibitor-1 (PAI-1) and urokinase-type plasminogen activator (uPA) play a crucial role in cancer progression. In the present study we examined the regulation of PAI-1 and uPA expressions in...