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Brian Telfer

Explore the profile of Brian Telfer including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 428
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Recent Articles
1.
Spadea A, Tirella A, Rios de la Rosa J, Lallana E, Mehibel M, Telfer B, et al.
Pharmaceutics . 2024 Oct; 16(10). PMID: 39458615
Conventional anticancer therapies often lack specificity, targeting both cancerous and normal cells, which reduces efficacy and leads to undesired off-target effects. An additional challenge is the presence of hypoxic regions...
2.
Sel K, Osman D, Zare F, Shahrbabak S, Brattain L, Hahn J, et al.
J Am Heart Assoc . 2024 Aug; 13(19):e031981. PMID: 39087582
The past several decades have seen rapid advances in diagnosis and treatment of cardiovascular diseases and stroke, enabled by technological breakthroughs in imaging, genomics, and physiological monitoring, coupled with therapeutic...
3.
Buller M, Fellin R, Bursey M, Galer M, Atkinson E, Beidleman B, et al.
Br J Sports Med . 2022 Jan; 56(8):446-451. PMID: 35022161
Objective: Exertional heat stroke (EHS), characterised by a high core body temperature (Tcr) and central nervous system (CNS) dysfunction, is a concern for athletes, workers and military personnel who must...
4.
Williamson J, Telfer B, Mullany R, Friedl K
Sensors (Basel) . 2021 Apr; 21(6). PMID: 33799420
Parkinson's disease (PD) is a chronic movement disorder that produces a variety of characteristic movement abnormalities. The ubiquity of wrist-worn accelerometry suggests a possible sensor modality for early detection of...
5.
Cersosimo F, Lonardi S, Bernardini G, Telfer B, Mandelli G, Santucci A, et al.
Int J Mol Sci . 2020 Jul; 21(15). PMID: 32717819
Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent patients characterized by high risk of metastatic progression and recurrence after therapy. Effective therapeutic management of this disease...
6.
Giurisato E, Lonardi S, Telfer B, Lussoso S, Risa-Ebri B, Zhang J, et al.
Cancer Res . 2020 Jun; 80(16):3319-3330. PMID: 32561530
The presence of immunosuppressive macrophages that become activated in the tumor microenvironment constitutes a major factor responsible for tumor growth and malignancy. In line with this knowledge, we report here...
7.
Rowling E, Miskolczi Z, Nagaraju R, Wilcock D, Wang P, Telfer B, et al.
Pigment Cell Melanoma Res . 2020 Mar; 33(5):695-708. PMID: 32145051
A major challenge for managing melanoma is its tumour heterogeneity based on individual co-existing melanoma cell phenotypes. These phenotypes display variable responses to standard therapies, and they drive individual steps...
8.
Youshani A, Rowlston S, OLeary C, Forte G, Parker H, Liao A, et al.
J Neuroinflammation . 2019 Feb; 16(1):25. PMID: 30722781
Background: Chimeric mouse models generated via adoptive bone marrow transfer are the foundation for immune cell tracking in neuroinflammation. Chimeras that exhibit low chimerism levels, blood-brain barrier disruption and pro-inflammatory...
9.
Majumdar A, Brattain L, Telfer B, Farris C, Scalera J
Annu Int Conf IEEE Eng Med Biol Soc . 2018 Nov; 2018:583-587. PMID: 30440464
Initial results are reported on automated detection of intracranial hemorrhage from CT, which would be valuable in a computer-aided diagnosis system to help the radiologist detect subtle hemorrhages. Previous work...
10.
Giurisato E, Xu Q, Lonardi S, Telfer B, Russo I, Pearson A, et al.
Proc Natl Acad Sci U S A . 2018 Mar; 115(12):E2801-E2810. PMID: 29507229
Owing to the prevalence of tumor-associated macrophages (TAMs) in cancer and their unique influence upon disease progression and malignancy, macrophage-targeted interventions have attracted notable attention in cancer immunotherapy. However, tractable...