Brian R Fritz
Overview
Explore the profile of Brian R Fritz including associated specialties, affiliations and a list of published articles.
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13
Citations
4526
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Recent Articles
1.
Bicknell A, Reid D, Licata M, Jones A, Cheng Y, Li M, et al.
Cell Rep
. 2024 Apr;
43(4):114098.
PMID: 38625793
Developing an effective mRNA therapeutic often requires maximizing protein output per delivered mRNA molecule. We previously found that coding sequence (CDS) design can substantially affect protein output, with mRNA variants...
2.
Deal C, Richards A, Yeung T, Maron M, Wang Z, Lai Y, et al.
Cell Rep Med
. 2023 Nov;
4(11):101253.
PMID: 37918405
Colonization of the gut and airways by pathogenic bacteria can lead to local tissue destruction and life-threatening systemic infections, especially in immunologically compromised individuals. Here, we describe an mRNA-based platform...
3.
Hammerling M, Fritz B, Yoesep D, Kim D, Carlson E, Jewett M
Nat Commun
. 2020 Mar;
11(1):1108.
PMID: 32111839
Directed evolution of the ribosome for expanded substrate incorporation and novel functions is challenging because the requirement of cell viability limits the mutations that can be made. Here we address...
4.
Fritz B, Jamil O, Jewett M
Nucleic Acids Res
. 2015 Apr;
43(9):4774-84.
PMID: 25897121
In vitro construction of Escherichia coli ribosomes could elucidate a deeper understanding of these complex molecular machines and make possible the production of synthetic variants with new functions. Toward this...
5.
Liu Y, Fritz B, Anderson M, Schoborg J, Jewett M
ACS Synth Biol
. 2014 Aug;
4(4):454-62.
PMID: 25079899
Complete cell-free synthesis of ribosomes could make possible minimal cell projects and the construction of variant ribosomes with new functions. Recently, we reported the development of an integrated synthesis, assembly,...
6.
Fritz B, Jewett M
Nucleic Acids Res
. 2014 May;
42(10):6774-85.
PMID: 24792158
In vitro ribosome construction could enable studies of ribosome assembly and function, provide a route toward constructing minimal cells for synthetic biology, and permit the construction of ribosome variants with...
7.
Jewett M, Fritz B, Timmerman L, Church G
Mol Syst Biol
. 2013 Jun;
9:678.
PMID: 23799452
Purely in vitro ribosome synthesis could provide a critical step towards unraveling the systems biology of ribosome biogenesis, constructing minimal cells from defined components, and engineering ribosomes with new functions....
8.
Wyman S, Knouf E, Parkin R, Fritz B, Lin D, Dennis L, et al.
Genome Res
. 2011 Aug;
21(9):1450-61.
PMID: 21813625
Modification of microRNA sequences by the 3' addition of nucleotides to generate so-called "isomiRs" adds to the complexity of miRNA function, with recent reports showing that 3' modifications can influence...
9.
Fritz B, Timmerman L, Daringer N, Leonard J, Jewett M
J Biomed Biotechnol
. 2010 Nov;
2010:232016.
PMID: 21052559
Synthetic biology is a nascent technical discipline that seeks to enable the design and construction of novel biological systems to meet pressing societal needs. However, engineering biology still requires much...
10.
Pomerantz M, Beckwith C, Regan M, Wyman S, Petrovics G, Chen Y, et al.
Cancer Res
. 2009 Jun;
69(13):5568-74.
PMID: 19549893
Polymorphisms at 8q24 are robustly associated with prostate cancer risk. The risk variants are located in nonprotein coding regions and their mechanism has not been fully elucidated. To further dissect...