Brian J Staskawicz
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Explore the profile of Brian J Staskawicz including associated specialties, affiliations and a list of published articles.
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55
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4819
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Recent Articles
1.
Karavolias N, Patel-Tupper D, Gallegos Cruz A, Litvak L, Lieberman S, Tjahjadi M, et al.
Plant Biotechnol J
. 2024 Oct;
22(12):3442-3452.
PMID: 39425265
Cis-regulatory element editing can generate quantitative trait variation that mitigates extreme phenotypes and harmful pleiotropy associated with coding sequence mutations. Here, we applied a multiplexed CRISPR/Cas9 approach, informed by bioinformatic...
2.
Liu F, Yang Z, Wang C, You Z, Martin R, Qiao W, et al.
Cell
. 2024 Aug;
187(18):4877-4889.e15.
PMID: 39094568
Innate immune responses to microbial pathogens are regulated by intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) in both the plant and animal kingdoms. Across plant innate immune systems,...
3.
Jones J, Staskawicz B, Dangl J
Cell
. 2024 Apr;
187(9):2095-2116.
PMID: 38670067
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to...
4.
Sharma A, Li J, Wente R, Minsavage G, Gill U, Ortega A, et al.
Front Plant Sci
. 2023 Jun;
14:1061803.
PMID: 37275256
Bacterial spot caused by is a major disease of pepper ( L.) in warm and humid production environments. Use of genetically resistant cultivars is an effective approach to manage bacterial...
5.
Gomez M, Berkoff K, Gill B, Iavarone A, Lieberman S, Ma J, et al.
Front Plant Sci
. 2023 Apr;
13:1079254.
PMID: 37007603
Cassava () is a starchy root crop that supports over a billion people in tropical and subtropical regions of the world. This staple, however, produces the neurotoxin cyanide and requires...
6.
Paralog editing tunes rice stomatal density to maintain photosynthesis and improve drought tolerance
Karavolias N, Patel-Tupper D, Seong K, Tjahjadi M, Gueorguieva G, Tanaka J, et al.
Plant Physiol
. 2023 Mar;
192(2):1168-1182.
PMID: 36960567
Rice (Oryza sativa) is of paramount importance for global nutrition, supplying at least 20% of global calories. However, water scarcity and increased drought severity are anticipated to reduce rice yields...
7.
Tamborski J, Seong K, Liu F, Staskawicz B, Krasileva K
Mol Plant Microbe Interact
. 2023 Mar;
36(7):434-446.
PMID: 36867580
Many resistance genes deployed against pathogens in crops are intracellular nucleotide-binding (NB) leucine-rich repeat (LRR) receptors (NLRs). The ability to rationally engineer the specificity of NLRs will be crucial in...
8.
Martin R, Qi T, Zhang H, Liu F, King M, Toth C, et al.
Science
. 2020 Dec;
370(6521).
PMID: 33273074
Plants and animals detect pathogen infection using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or indirectly recognize pathogen effectors and activate an immune response. How effector sensing triggers NLR...
9.
Horsefield S, Burdett H, Zhang X, Manik M, Shi Y, Chen J, et al.
Science
. 2019 Aug;
365(6455):793-799.
PMID: 31439792
SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich...
10.
Tian W, Hou C, Ren Z, Wang C, Zhao F, Dahlbeck D, et al.
Nature
. 2019 Jul;
572(7767):131-135.
PMID: 31316205
Pathogen-associated molecular patterns (PAMPs) activate innate immunity in both animals and plants. Although calcium has long been recognized as an essential signal for PAMP-triggered immunity in plants, the mechanism of...