Brian J Lestini
Overview
Explore the profile of Brian J Lestini including associated specialties, affiliations and a list of published articles.
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6
Citations
864
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Recent Articles
1.
Rizvi N, Mazieres J, Planchard D, Stinchcombe T, Dy G, Antonia S, et al.
Lancet Oncol
. 2015 Feb;
16(3):257-65.
PMID: 25704439
Background: Patients with squamous non-small-cell lung cancer that is refractory to multiple treatments have poor outcomes. We assessed the activity of nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor...
2.
Lestini B, Goldsmith K, Fluchel M, Liu X, Chen N, Goyal B, et al.
Cancer Biol Ther
. 2009 Jun;
8(16):1587-95.
PMID: 19556859
Neuroblastoma (NB) is a common, highly lethal pediatric cancer, with treatment failures largely attributable to the emergence of chemoresistance. The pro-survival Bcl2 homology (BH) proteins critically regulate apoptosis, and may...
3.
Kreiger P, Judkins A, Russo P, Biegel J, Lestini B, Assanasen C, et al.
Mod Pathol
. 2008 Nov;
22(1):142-50.
PMID: 18997735
Malignant rhabdoid tumor has traditionally been defined by its histologic phenotype. However, genetic investigations of malignant rhabdoid tumor have revealed a characteristic loss of or mutation in the INI1 gene...
4.
Lestini B, Church J
Pediatr Infect Dis J
. 2006 Jan;
25(1):87-9.
PMID: 16395115
We describe a patient with chronic granulomatous disease and receiving immunosuppressive therapy for refractory granulomatous colitis who developed fatal fulminant pneumonia, with Trichosporon pullulans isolated from multiple sites. This case...
5.
Sen Gupta A, Huang G, Lestini B, Sagnella S, Kottke-Marchant K, Marchant R
Thromb Haemost
. 2005 Jan;
93(1):106-14.
PMID: 15630499
Local drug delivery has become an important treatment modality for the prevention of thrombotic events following coronary angioplasty. In this study, we investigate the ability of liposomes bearing surface conjugated...
6.
Lestini B, Sagnella S, Xu Z, Shive M, Richter N, Jayaseharan J, et al.
J Control Release
. 2002 Jan;
78(1-3):235-47.
PMID: 11772464
Cardiovascular disease processes such as atherosclerosis, restenosis, and inflammation are typically localized to discrete regions of the vasculature, affording great opportunity for targeted pharmacological treatment. Liposomes are potentially advantageous targeted...