Brian Grone
Overview
Explore the profile of Brian Grone including associated specialties, affiliations and a list of published articles.
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11
Citations
226
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Recent Articles
1.
Rao A, Chen N, Kim M, Blumenfeld J, Yip O, Liang Z, et al.
Cell Stem Cell
. 2024 Nov;
32(1):86-104.e7.
PMID: 39500314
Despite strong evidence supporting the important roles of both apolipoprotein E4 (APOE4) and microglia in Alzheimer's disease (AD) pathogenesis, the effects of microglia on neuronal APOE4-related AD pathogenesis remain elusive....
2.
Rao A, Chen N, Kim M, Blumenfeld J, Yip O, Hao Y, et al.
bioRxiv
. 2023 Nov;
PMID: 38014339
Despite strong evidence supporting the involvement of both apolipoprotein E4 (APOE4) and microglia in Alzheimer's Disease (AD) pathogenesis, the effects of microglia on neuronal APOE4-driven AD pathogenesis remain elusive. Here,...
3.
Nelson M, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, et al.
Nat Neurosci
. 2023 Nov;
26(12):2104-2121.
PMID: 37957317
Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD), leading to earlier age of clinical onset and exacerbating pathologies. There is a critical need to...
4.
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Yip O, Rao A, et al.
Cell Rep
. 2023 Oct;
42(10):113252.
PMID: 37863057
Apolipoprotein E4 (APOE4) is an important driver of Tau pathology, gliosis, and degeneration in Alzheimer's disease (AD). Still, the mechanisms underlying these APOE4-driven pathological effects remain elusive. Here, we report...
5.
Tabuena D, Jang S, Grone B, Yip O, Aery Jones E, Blumenfeld J, et al.
bioRxiv
. 2023 Sep;
PMID: 37693533
The full impact of apolipoprotein E4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on neuronal and network function remains unclear. We found hippocampal region-specific network hyperexcitability in...
6.
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Grone B, Zilberter M, et al.
Nat Aging
. 2023 Apr;
3(3):275-296.
PMID: 37118426
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal...
7.
Taubes A, Nova P, Zalocusky K, Kosti I, Bicak M, Zilberter M, et al.
Nat Aging
. 2023 Apr;
1(12):1202.
PMID: 37117528
No abstract available.
8.
Taubes A, Nova P, Zalocusky K, Kosti I, Bicak M, Zilberter M, et al.
Nat Aging
. 2022 Sep;
1(10):932-947.
PMID: 36172600
The evident genetic, pathological, and clinical heterogeneity of Alzheimer's disease (AD) poses challenges for traditional drug development. We conducted a computational drug repurposing screen for drugs to treat apolipoprotein (apo)...
9.
Belonwu S, Li Y, Bunis D, Rao A, Warly Solsberg C, Oskotsky T, et al.
Front Aging Neurosci
. 2022 May;
14:749991.
PMID: 35572130
Alzheimer's Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic...
10.
Griffin A, Carpenter C, Liu J, Paterno R, Grone B, Hamling K, et al.
Commun Biol
. 2021 Jun;
4(1):680.
PMID: 34083748
Genetic engineering techniques have contributed to the now widespread use of zebrafish to investigate gene function, but zebrafish-based human disease studies, and particularly for neurological disorders, are limited. Here we...