Brian D Young
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Explore the profile of Brian D Young including associated specialties, affiliations and a list of published articles.
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11
Citations
338
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Recent Articles
1.
Muntean B, Marwari S, Li X, Sloan D, Young B, Wohlschlegel J, et al.
Proc Natl Acad Sci U S A
. 2021 Dec;
119(1).
PMID: 34934014
Cyclic adenosine monophosphate (cAMP) is a pivotal second messenger with an essential role in neuronal function. cAMP synthesis by adenylyl cyclases (AC) is controlled by G protein-coupled receptor (GPCR) signaling...
2.
Young B, Sha J, Vashisht A, Wohlschlegel J
J Proteome Res
. 2021 Aug;
20(9):4318-4330.
PMID: 34342229
G-protein-coupled receptors (GPCRs) initiate intracellular signaling events through heterotrimeric G-protein α-subunits (Gα) and the βγ-subunit dimer (Gβγ). In this study, we utilized mass spectrometry to identify novel regulators of Gβγ...
3.
Hu X, Weston T, He C, Jung R, Heizer P, Young B, et al.
Elife
. 2019 Sep;
8.
PMID: 31486771
Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind...
4.
Sinclair P, Ryan S, Bashton M, Hollern S, Hanna R, Case M, et al.
Leukemia
. 2019 Mar;
33(8):1881-1894.
PMID: 30816328
In more than 30% of B-cell precursor acute lymphoblastic leukaemia (B-ALL), chromosome 21 sequence is overrepresented through aneuploidy or structural rearrangements, exemplified by intrachromosomal amplification of chromosome 21 (iAMP21). Although...
5.
Loveless T, Topacio B, Vashisht A, Galaang S, Ulrich K, Young B, et al.
PLoS Genet
. 2015 Jun;
11(6):e1005292.
PMID: 26091241
The Skp1-Cul1-F box complex (SCF) associates with any one of a number of F box proteins, which serve as substrate binding adaptors. The human F box protein βTRCP directs the...
6.
Reaves M, Young B, Hosios A, Xu Y, Rabinowitz J
Nature
. 2013 Aug;
500(7461):237-41.
PMID: 23903661
Cellular metabolism converts available nutrients into usable energy and biomass precursors. The process is regulated to facilitate efficient nutrient use and metabolic homeostasis. Feedback inhibition of the first committed step...
7.
Young B, Weiss D, Zurita-Lopez C, Webb K, Clarke S, McBride A
Biochemistry
. 2012 Jun;
51(25):5091-104.
PMID: 22650761
We have characterized the posttranslational methylation of Rps2, Rps3, and Rps27a, three small ribosomal subunit proteins in the yeast Saccharomyces cerevisiae, using mass spectrometry and amino acid analysis. We found...
8.
Castro P, Khare S, Young B, Clarke S
PLoS One
. 2012 Jan;
7(1):e29984.
PMID: 22279556
The nematode Caenorhabditis elegans arrests development at the first larval stage if food is not present upon hatching. Larvae in this stage provide an excellent model for studying stress responses...
9.
Webb K, Al-Hadid Q, Zurita-Lopez C, Young B, Lipson R, Clarke S
J Biol Chem
. 2011 Apr;
286(21):18405-13.
PMID: 21460220
Modification of proteins of the translational apparatus is common in many organisms. In the yeast Saccharomyces cerevisiae, we provide evidence for the methylation of Rpl1ab, a well conserved protein forming...
10.
Webb K, Zurita-Lopez C, Al-Hadid Q, Laganowsky A, Young B, Lipson R, et al.
J Biol Chem
. 2010 Sep;
285(48):37598-606.
PMID: 20864530
We have shown that Rpl3, a protein of the large ribosomal subunit from baker's yeast (Saccharomyces cerevisiae), is stoichiometrically monomethylated at position 243, producing a 3-methylhistidine residue. This conclusion is...