Brian Aizenstein
Overview
Explore the profile of Brian Aizenstein including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
396
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0
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Recent Articles
1.
Okuzumi T, Ducker G, Zhang C, Aizenstein B, Hoffman R, Shokat K
Mol Biosyst
. 2010 Jun;
6(8):1389-402.
PMID: 20582381
The kinase Akt is a key signaling node in regulating cellular growth and survival. It is implicated in cancer by mutation and its role in the downstream transmission of aberrant...
2.
Williams O, Houseman B, Kunkel E, Aizenstein B, Hoffman R, Knight Z, et al.
Chem Biol
. 2010 Mar;
17(2):123-34.
PMID: 20189103
PI3Kdelta and PI3Kgamma regulate immune cell signaling, while the related PI3Kalpha and PI3Kbeta regulate cell survival and metabolism. Selective inhibitors of PI3Kdelta/gamma represent a potential class of anti-inflammatory agents lacking...
3.
Okuzumi T, Fiedler D, Zhang C, Gray D, Aizenstein B, Hoffman R, et al.
Nat Chem Biol
. 2009 May;
5(7):484-93.
PMID: 19465931
The kinase Akt plays a central role as a regulator of multiple growth factor input signals, thus making it an attractive anticancer drug target. A-443654 is an ATP-competitive Akt inhibitor....
4.
Apsel B, Blair J, Gonzalez B, Nazif T, Feldman M, Aizenstein B, et al.
Nat Chem Biol
. 2008 Oct;
4(11):691-9.
PMID: 18849971
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed,...
5.
Nevilie M, Selzer R, Aizenstein B, Maguire M, Hogan K, Walton R, et al.
Biotechniques
. 2002 Jun;
Suppl:34-8, 40-3.
PMID: 12083395
The cytochrome p450 (CYP) superfamily comprises enzymes that play an essential role in the transformation of medically relevant compounds. Accurate genotyping of polymorphisms in members of this family is drawing...